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https://www.sciencedirect.com/science/article/pii/S0168365913009681
This study aims at developing chitosan-based nanoparticles suitable for an intravenous administration of small interfering RNA (siRNA) able to achieve (i) high gene silencing without cytotoxicity and (ii) stability in biological media including blood.Author: Héloïse Ragelle, Raphaël Riva, G. Vandermeulen, B. Naeye, Vincent Pourcelle, C. S. Le Duff, C. D'Hae...
https://www.sciencedirect.com/science/article/pii/S0021979717310755
Jan 15, 2018 · To benefit from the biocompatibility of lipid nanoparticles associated with the transfection ability of chitosan, small chitosan lipid nanoparticles (CS-LNPs) dedicated to SiRNA delivery were formulated by an easy-to-implement one-step process.Author: Özgül Tezgel, Anna Szarpak-Jankowska, Amandine Arnould, Rachel Auzély-Velty, Isabelle Texier
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250949/
Dec 01, 2014 · Chitosan nanoparticles were prepared using ultrasonication methodology at specific amplitudes and times of sonication. Subsequently, small interfering RNA (siRNA) was added to the solution at predetermined values of nitrogen to phosphorous ratio (N/P), and stirring time.Author: Elina Esmaeilzadeh Gharehdaghi, Amir Amani, Mohammad Reza Khoshayand, Mehdi Banan, Elika Esmaeilzade...
https://www.hindawi.com/journals/ijbm/2013/146320/
Chitosan nanoparticles (CS NPs) exhibit good physicochemical properties as drug delivery systems. ... International Journal of Biomaterials / 2013 / Article. Article Sections. On this page. ... “Development and characterisation of chitosan nanoparticles for siRNA delivery,” Journal of Controlled Release, vol. 115, no. 2, pp. 216–225, 2006.Author: Haliza Katas, Maria Abdul Ghafoor Raja, Kai Leong Lam
https://pubs.acs.org/doi/abs/10.1021/nn300106t
Composite nanofibers of biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) encapsulating chitosan/siRNA nanoparticles (NPs) were prepared by electrospinning. Acidic/alkaline hydrolysis and a bulk/surface degradation mechanism were investigated in order to achieve an optimized release profile for prolonged and efficient gene silencing.Author: Menglin Chen, Shan Gao, Mingdong Dong, Jie Song, Chuanxu Yang, Kenneth Alan Howard, Jørgen Kjems, Fl...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465927/
Stability, Intracellular Delivery, and Release of siRNA from Chitosan Nanoparticles Using Different Cross-Linkers. ... CS-TPP-siRNA nanoparticles infiltrated cells and were primarily distributed in the cytoplasm, which is in agreement with previous observations (Fig 10D–10F).Author: Maria Abdul Ghafoor Raja, Haliza Katas, Thum Jing Wen
https://link.springer.com/protocol/10.1007%2F978-1-4939-7138-1_14
Jul 21, 2017 · To overcome challenges with in vivo delivery of microRNAs related to stability, cellular uptake, and specific delivery, our group has developed and characterized chitosan nanoparticles for nucleotide delivery. This platform allows for robust target modulation and antitumor activity following intravenous administration.Author: Merve Denizli, Burcu Aslan, Lingegowda S. Mangala, Dahai Jiang, Cristian Rodriguez-Aguayo, Gabriel L...
https://www.hindawi.com/journals/jphar/2013/812387/
In the present study, we have utilized the ability of surface functionalized chitosan nanoparticles to deliver siRNA to the brain, following an intranasal route. The study is a qualitative investigation of the siRNA delivery through the surface functionalized chitosan nanoparticles.Author: Meenakshi Malhotra, Catherine Tomaro-Duchesneau, Shyamali Saha, Satya Prakash
https://www.researchgate.net/publication/283524319_Chitosan_Nanoparticles_for_SiRNA_Delivery_In_Vitro
Some of the examples of chitosan nanoparticle for gene delivery include oligonucleotide and plasmid DNA via galactosylated chitosan vector [169], delivery of siRNA nanoparticles for gene therapy ...
https://www.researchgate.net/publication/318629946_Chitosan_Nanoparticles_for_miRNA_Delivery
Chitosan Nanoparticles for miRNA Delivery. ... This review will present recent improvements in chitosan-based siRNA delivery systems that overcome many of these system's previous pitfalls and pave ...
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