Chitosan Nanoparticles For Drug Delivery

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Chitosan nanoparticles for oral drug and gene delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426784/
    Chitosan nanoparticle delivery led to 73% greater relative bioavailability of drug compared with the commercial microemulsion Neoral ®, while delivery of similarly sized cationic nanoparticles formed with gelatin-A led to 18% greater bioavailability. However, delivery of smaller negatively charged sodium glycocholate nanoparticles led to decreased bioavailability, indicating the cationic nature of the …Author: Katherine Bowman, Kam W Leong

Special Issue "Chitosan Nanoparticles in Drug Delivery"

    https://www.mdpi.com/journal/pharmaceutics/special_issues/chitosan_drug_delivery
    Sitagliptin (SGN) is an antidiabetic drug used for treatment of diabetes mellitus type II. The objectives of this study were to formulate SGN in form of thiolated chitosan (TC) nanoparticles to enhance the mucoadhesion properties of SGN to the gastrointestinal tract, prolong drug release, decrease side effects, and enhance patient compliance.

Recent advances of chitosan nanoparticles as drug carriers

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090273/
    Apr 11, 2011 · As a nonvirus carrier, chitosan has excellent biocompatibility and biodegradation, which has led to increasing application of chitosan nanoparticles in gene drug delivery.54,55 Gene silencing mediated by double-stranded small interfering RNA (siRNA) has been widely investigated as a potential therapeutic approach for diseases caused by genetic defects.54 However, its application is restricted …Author: Jun Jie Wang, Zhao Wu Zeng, Ren Zhong Xiao, Tian Xie, Guang Lin Zhou, Xiao Ri Zhan, Shu Ling Wang

Crosslinked Chitosan Nanoparticles for Drug Delivery ...

    https://chitolytic.com/crosslinked-chitosan-nanoparticles/
    Nanoparticle drug delivery systems, including nanospheres, nanocapsules, nanomicelles, nanoliposomes, etc., are nanometric carriers used to deliver drugs or biomolecules by trapping active agents in their interior structures and/or adsorbing them onto their exterior surfaces. 1,10–11 Presently, nanoparticles (NPs) have been widely used to deliver drugs, polypeptides, proteins, vaccines, …

Degradability of chitosan micro/nanoparticles for ...

    https://www.cell.com/heliyon/fulltext/S2405-8440(19)31154-5
    May 15, 2019 · The micro/nanoparticulate forms of chitosan are reported to enhance the efficiency of drug delivery with better physicochemical properties including improved solubility and bioavailability. This polymer is known to be biodegradable and biocompatible; however, crosslinked chitosan particles may not be biodegradable.Author: Nazrul Islam, Isra Dmour, Mutasem O Taha

Chitosan nanoparticles: A promising system for drug delivery

    https://www.researchgate.net/publication/284689097_Chitosan_nanoparticles_A_promising_system_for_drug_delivery
    Chitosan nanoparticles (CSNPs) have been extensively applied in medical and pharmaceutical fields as promising drug delivery systems. Despite that, the safety of CSNPs …Author: Waree Tiyaboonchai

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