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http://www.pharmtech.com/achieving-zero-order-release-kinetics-using-multi-step-diffusion-based-drug-delivery
May 02, 2014 · Abstract: Zero-order release, in which a drug is released at a constant rate, is the ultimate goal of all controlled-release drug-delivery mechanisms. It leads, in principle, to the best control of plasma concentration and offers several advantages, including improved patient compliance and reduction in the frequency of drug administration.
https://arizona.pure.elsevier.com/en/publications/multiplehole-approach-to-zeroorder-release
We describe an approach to zero‐order drug delivery systems that utilizes a device consisting of multiple holes uniformly distributed in an impermeable membrane. The interior of the device is filled with a suspension of a drug in a polymeric matrix. Near zero‐order release is attained by using the proper density and configuration of holes ...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/controlled-drug-release
10.8.5.1 Zero-Order Extravascular Drug Delivery. A number of controlled drug release approaches deliver drug at a steady rate into an extravascular region of the body. Examples include transdermal patches, implantable pumps, and intramuscular depot injections.
https://www.ondrugdelivery.com/zero-order-sustained-drug-delivery-retina-nanoporous-film-device/
The device itself degrades safely later on, after the drug payload has been completely delivered. Unlike many sustained delivery technologies, these nano-engineered polymer films are functionally tuneable to achieve a zero-order release profile such that drug concentration falls within a narrow range over the course of several months.
https://www.nature.com/articles/s41598-017-05898-6
Jul 17, 2017 · The key goal of a release system is to maintain the plasma drug concentration within the therapeutic window for a prolonged period of time. For zero-order release carriers, as the drug is released at constant rate, it will be possible to maintain the plasma drug concentration constant.Author: Ya-Nan Zhao, Xiaoyu Xu, Na Wen, Rui Song, Qingbin Meng, Ying Guan, Siqi Cheng, Danni Cao, Yansheng D...
http://jresm.org/archive/resm2020.178na0122.pdf
Fig. 3 Fit of Zero Order model function to the drug release data. Fig. 4 Fit of First Order model function to the drug release data. As seen from the Figure 4, vertical axes is different from the Figure 3. And function behaves linear with negative slope thanks to nature of …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142099/
Sep 28, 2014 · After a decade of extensive efforts it was realized that zero-order delivery was not really necessary to develop sustained drug delivery systems. First, zero-order release does not result in maintenance of the constant drug concentration in the blood. This is particularly obvious for oral delivery systems.Author: Kinam Park
https://www.sciencedirect.com/science/article/pii/B9780081000922000059
A reservoir system should provide zero-order release of the drug over the entire delivery period, which requires that the reservoir material remain saturated with the drug over the period of product application. This can usually be achieved by formulating the drug as a suspension (Walters & Brain, 2009). 5.3.
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