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https://www.ncbi.nlm.nih.gov/pubmed/19290841
Chitosan nanoparticles for drug delivery to the eye. Paolicelli P(1), de la Fuente M, Sánchez A, Seijo B, Alonso MJ. Author information: (1)University of Santiago de Compostela, Department of Pharmacy and Pharmaceutical Technology, Campus Sur 15782, Santiago de Compostela, Spain.Author: Patrizia Paolicelli, Maria de la Fuente, Alejandro Sánchez, Begoña Seijo, María José Alonso
https://www.tandfonline.com/doi/abs/10.1517/17425240902762818
The purpose of this review is to provide the reader with an overview of the advances made in ocular delivery of bioactive molecules by means of chitosan-based nanosystems, and their potential relevance in clinical use. The studies described clearly emphasise that chitosan-based nanostructures are versatile systems that can be tailor-made according to required compositions, surface ...Author: Patrizia Paolicelli, Maria de la Fuente, Alejandro Sánchez, Begoña Seijo, María José Alonso
https://www.researchgate.net/publication/24205168_Chitosan_nanoparticles_for_drug_delivery_to_the_eye
Chitosan is a polycationic saccharide derived from naturally available chitin, which constitutes an ideal candidate for drug delivery applications in the eye [71]. It is abundant, biocompatible ...
https://www.sciencedirect.com/science/article/pii/S0169409X17300364
Chitosan has arisen as a promising material for the improvement of drug delivery to the ocular mucosa and is most extensively studied polysaccharide. Chitosan is a cationic linear polysaccharide copolymer of 1,4-(2-amino-2-deoxy- d -glucopyranose) and 1,4-(2-acetamido-2-deoxy- d -glucopyranose).Author: Dileep R. Janagam, Linfeng Wu, Tao L. Lowe
https://www.frontiersin.org/articles/10.3389/fphar.2020.00317/full
The poor solubility and permeability of most chemotherapeutic drugs lead to unsatisfactory bioavailability combined with insufficient drug concentration. In this study, positively charged nanoparticles based on chitosan were developed and synthesized to enhance tumor penetration capability of 10-Hydroxycamptothecin (HCPT) in order to improve the chemotherapeutic effect of melanoma. The …
https://www.sciencedirect.com/science/article/pii/S0378517319309883
Inspired by this early significant progress, we rationally designed and synthesized a series of dexamethasone-glycol chitosan (Dex-GCS) conjugates, which could self-assemble into nanoparticles spontaneously in aqueous solution acting as a “self-delivery” system for topical ophthalmic drug delivery.Author: Ailing Yu, Hui Shi, Hui Liu, Zhishu Bao, Mali Dai, Dan Lin, Deqing Lin, Xu Xu, Xingyi Li, Yuqin Wang
https://www.sciencedirect.com/science/article/pii/S0939641112001038
Chitosan-based formulations used for ophthalmic drug delivery are hydrogels [43], nanoparticles [44], and coated colloidal systems [45]. Chitosan-based systems have the potential for improving the retention and biodistribution of drugs applied topically onto the eye. Making use of …Author: Andreas Bernkop-Schnürch, Sarah Dünnhaupt
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693026/
Jun 18, 2013 · Nanoparticles (NPs) have been designed to overcome the barriers, increase the drug penetration at the target site and prolong the drug levels by few internals of drug administrations in lower doses without any toxicity compared to the conventional eye drops. With the aid of high specificity and multifunctionality,...Author: Hong-Yan Zhou, Ji-Long Hao, Shuang Wang, Yu Zheng, Wen-Song Zhang
https://www.sciencedirect.com/science/article/pii/S0378517301007608
Aug 14, 2001 · In the present study, the potential of chitosan (CS) nanoparticles as a new vehicle for the improvement of the delivery of drugs to the ocular mucosa was investigated. Cyclosporin A (CyA) was chosen as a model compound because of its potential usefulness for …Author: Angela M. De Campos, Alejandro Sánchez, Marı́a J. Alonso
https://www.researchgate.net/publication/51627832_Chitosan_nanoparticles_for_controlled_delivery_of_brimonidine_tartrate_to_the_ocular_membrane
Chitosan nanoparticles for controlled delivery of brimonidine tartrate to the ocular membrane Article (PDF Available) in Pharmazie 66(8):594-9 · August 2011 with 295 Reads How we measure 'reads'
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