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https://www.sciencedirect.com/science/article/pii/S0939641100000886
The ideal antisense oligonucleotide delivery vehicle should be small enough (<30 kDa) to be able to pass through the capillary walls to exit the bloodstream, and should promote oligonucleotide penetration into the target cell. Most importantly, it must stably bind oligonucleotides until it …Author: Irina Lebedeva, Lyuba Benimetskaya, C.A. Stein, Maria Vilenchik
https://www.ncbi.nlm.nih.gov/pubmed/10840195
Cellular delivery of antisense oligonucleotides. Lebedeva I(1), Benimetskaya L, Stein CA, Vilenchik M. Author information: (1)Columbia University, NY, New York, USA. Antisense oligonucleotides can be successfully employed to inhibit specifically gene expression.Author: Irina Lebedeva, Lyuba Benimetskaya, C.A. Stein, Maria Vilenchik
https://www.sciencedirect.com/science/article/pii/S1359644600003263
The design and development of antisense oligonucleotides and ribozymes for the treatment of diseases arising from genetic abnormalities has become a real possibility over the past few years. Improvements in oligonucleotide chemistry have led to the synthesis of nucleic acids that are relatively stable in the biological milieu.Author: Marcus D Hughes, Majad Hussain, Qamar Nawaz, Pakeeza Sayyed, Saghir Akhtar
https://www.ncbi.nlm.nih.gov/pubmed/21381985
Cellular delivery of siRNA and antisense oligonucleotides via receptor-mediated endocytosis. Ming X(1). Author information: (1)Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.Author: Xin Ming
https://www.researchgate.net/publication/12478486_Cellular_delivery_of_antisense_oligonucleotides
Request PDF Cellular delivery of antisense oligonucleotides Antisense oligonucleotides can be successfully employed to inhibit specifically gene expression. However, many oligonucleotide ...
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(16)30083-X
Jan 01, 2012 · There are two main ways of utilizing peptide vectors for the delivery of antisense oligonucleotides and siRNA. The first method involves chemical synthesis of peptides that are modified to enable covalent conjugation to oligonucleotides or other cargo types . Such conjugation reactions may be carried out either on solid support or in solution, and often result in high yields.Author: Peter Järver, Thibault Coursindel, Samir El Andaloussi, Samir El Andaloussi, Caroline Godfrey, Matth...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475625/
Jun 16, 2008 · CELLULAR DELIVERY OF OLIGONUCLEOTIDE CONJUGATES AND COMPLEXES. In this section, we discuss the use of CPPs and CTLs in the delivery of antisense and siRNA oligonucleotides. Emphasis here is on cellular studies, while in vivo work is discussed in a following section. As a prelude, it is important to recall that oligonucleotides do not permeate intact cell …Author: Rudy Juliano, Md. Rowshon Alam, Vidula Dixit, Hyumin Kang
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