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https://www.sciencedirect.com/science/article/pii/S0169409X02001825
G. Aldrian-Herrada, M.G. Desarmenien, H. Orcel, L. Boissin-Agasse, J. Mery, J. Brugidou, A. RabieA peptide nucleic acid (PNA) is more rapidly internalized in cultured neurons when coupled to a retro-inverso delivery peptide. The antisense activity depresses the target mRNA and protein in magnocellular oxytocin neuronsAuthor: Uffe Koppelhus, Peter E. Nielsen
https://www.sciencedirect.com/science/article/abs/pii/S0169409X02001825
Peptide nucleic acid (PNA) is a DNA mimic having a pseudopeptide backbone that makes it extremely stable in biological fluids. PNA binds complementary RNA and DNA with high affinity and specificity. These qualities make PNA a leading agent among ‘third generation’ antisense and antigene agents.Author: Uffe Koppelhus, Peter E. Nielsen
https://www.ncbi.nlm.nih.gov/pubmed/12564980
Feb 10, 2003 · Cellular delivery of peptide nucleic acid (PNA). Koppelhus U(1), Nielsen PE. Author information: (1)Biochemistry Laboratory B, Center for Biomolecular Recognition, Department of Medical Biochemistry and Genetics, The Panum Institute, Blegdamsvej 3c, 2200 N Copenhagen, Denmark.Author: Uffe Koppelhus, Peter E. Nielsen
https://www.researchgate.net/publication/10919478_Cellular_delivery_of_peptide_nucleic_acid_PNA
Cellular delivery of peptide nucleic acid (PNA) Peptide nucleic acid (PNA) is a DNA mimic having a pseudopeptide backbone that makes it extremely stable in biological fluids. PNA binds complementary RNA and DNA with high affinity and specificity. These qualities make PNA a leading agent among "third generation" antisense and antigene agents.
https://www.ncbi.nlm.nih.gov/pubmed/32088870
Cellular delivery methods are a prerequisite for cellular studies with PNA. This chapter describes PNA cellular delivery using cell-penetrating peptide (CPP)-PNA conjugates and transfection of PNA-ligand conjugates mediated by cationic lipids. Furthermore, two endosomolytic procedures employing chloroquine treatment or photochemical ...Author: Takehiko Shiraishi, Mahdi Ghavami, Peter E. Nielsen
https://www.tandfonline.com/doi/pdf/10.4161/adna.18739
Key words: antisense, carrier, cellular delivery, cell penetrating peptide (CPP), peptide nucleic acid (PNA), siRNA and substantial efforts have been invested in these for gene ther - apy, 4 but they pose challenges in terms of immune responses.
https://www.researchgate.net/publication/259114594_Cellular_Delivery_of_Peptide_Nucleic_Acids_PNAs
Cellular Delivery of Peptide Nucleic Acids (PNAs) Cellular delivery methods are a prerequisite for cellular studies with PNA. This chapter describes PNA cellular delivery using cell-penetrating peptide (CPP)-PNA conjugates and transfection of PNA-ligand conjugates mediated by cationic lipids.
https://www.pnabio.com/peptide-nucleic-acid
PNA (Peptide Nucleic Acid) is an artificially synthesized polymer similar to DNA or RNA. The various purine and pyrimidine bases are linked to the backbone by methylene carbonyl bonds as in peptides. Since PNA contains no charged phosphate groups, the binding between PNA and DNA is stronger than that between DNA and DNA due to the lack of ...
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