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https://www.ncbi.nlm.nih.gov/pubmed/21381985
Cellular delivery of siRNA and antisense oligonucleotides via receptor-mediated endocytosis. Ming X(1). Author information: (1)Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. [email protected]: Xin Ming
https://www.researchgate.net/publication/50303167_Cellular_delivery_of_siRNA_and_antisense_oligonucleotides_via_receptor-mediated_endocytosis
Cellular delivery of siRNA and antisense oligonucleotides via receptor-mediated endocytosis Article · Literature Review in Expert Opinion on Drug Delivery 8(4):435-49 · March 2011 with 64 ReadsAuthor: Xin Ming
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475625/
Jun 16, 2008 · CELLULAR DELIVERY OF OLIGONUCLEOTIDE CONJUGATES AND COMPLEXES. In this section, we discuss the use of CPPs and CTLs in the delivery of antisense and siRNA oligonucleotides. Emphasis here is on cellular studies, while in vivo work is discussed in a following section. As a prelude, it is important to recall that oligonucleotides do not permeate ...Author: Rudy Juliano, Md. Rowshon Alam, Vidula Dixit, Hyumin Kang
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(16)30083-X.pdf
mediated strategies for delivery of antisense oligonucleotides and siRNA into cells in culture and also in in vivo applica-tions, and points to prospects for clinical development. MODES OF ACTION OF OLIGONUCLEOTIDE AND siRNA THERAPEUTICS There are several ways that short oligonucleotides and siRNA can affect cellular processes, schematically ...
https://www.tandfonline.com/doi/abs/10.1517/17425247.2011.561313
Apr 21, 2009 · Cellular delivery of siRNA and antisense oligonucleotides via receptor-mediated endocytosis Xin Ming The University of North Carolina at Chapel Hill, UNC Eshelman School of Pharmacy, Division of Molecular Pharmaceutics, Chapel Hill, NC 27599, USA +1 919 966 4343; [email protected]: Xin Ming
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(16)30083-X
Jan 01, 2012 · This review concentrates on recent progress (since 2007) in all of the various peptide-mediated strategies for delivery of antisense oligonucleotides and siRNA into cells in culture and also in in vivo applications, and points to prospects for clinical development.Author: Peter Järver, Thibault Coursindel, Samir El Andaloussi, Samir El Andaloussi, Caroline Godfrey, Matth...
https://academic.oup.com/nar/article/36/8/2764/2410250
Mar 26, 2008 · A potentially more promising strategy is to deliver antisense and siRNA oligonucleotides via receptor-mediated endocytosis by linking the oligonucleotide to a targeting moiety that binds with high affinity to a cell surface receptor capable of undergoing internalization.Author: Rowshon Alam, Vidula Dixit, Hyunmin Kang, Zi-bo Li, Xiaoyuan Chen, JoAnn Trejo, Michael S. Fisher, R...
https://pubs.acs.org/doi/abs/10.1021/ja102635c
Selective delivery of antisense or siRNA oligonucleotides to cells and tissues via receptor-mediated endocytosis is becoming an important approach for oligonucleotide-based pharmacology. In most cases receptor targeting has been attained using antibodies or peptide-type ligands. Thus, there are few examples of delivering oligonucleotides using the plethora of small-molecule receptor-specific ...Author: Osamu Nakagawa, Xin Ming, Leaf Huang, Rudolph L. Juliano
https://academic.oup.com/nar/article/36/12/4158/1132931
Jun 16, 2008 · CELLULAR DELIVERY OF OLIGONUCLEOTIDE CONJUGATES AND COMPLEXES. In this section, we discuss the use of CPPs and CTLs in the delivery of antisense and siRNA oligonucleotides. Emphasis here is on cellular studies, while in vivo work is discussed in a following section. As a prelude, it is important to recall that oligonucleotides do not permeate ...Author: Rudy Juliano, Md. Rowshon Alam, Vidula Dixit, Hyumin Kang
https://www.sciencedirect.com/topics/neuroscience/antisense-oligonucleotide
Stanley T. Crooke, in Encyclopedia of Cancer (Second Edition), 2002. Antisense oligonucleotides are used to hybridize to a specific RNA molecule in vivo and thereby to inhibit its subsequent use; in most cases, the target RNA is a messenger RNA (mRNA), which cannot then be translated into a protein. Once the gene sequence of interest is known, an antisense oligonucleotide with the ...
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