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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856437/
Oct 18, 2013 · Antisense oligonucleotides are powerful tools to regulate gene expression in cells and model organisms. However, a transfection or microinjection is needed for efficient delivery of the antisense agent. We report the conjugation of multiple HIV TAT peptides to a hairpin-protected antisense agent through a light-cleavable nucleobase caging group.Author: Jeane Marie Govan, Rajendra Uprety, Meryl Thomas, Hrvoje Lusic, Mark O. Lively, Alexander Deiters
https://www.sciencedirect.com/science/article/pii/S0939641100000886
In summary, the number of potential cellular delivery systems for antisense oligonucleotides has expanded tremendously over the past several years. However, it is not clear which of the many currently available technologies provides optimal delivery, defined …Author: Irina Lebedeva, Lyuba Benimetskaya, C.A. Stein, Maria Vilenchik
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045790/
Electroporation is potentially a very powerful technique for both in vitro cellular and in vivo drug delivery, particularly relating to oligonucleotides and their analogs for genetic therapy. Using a sensitive and quantitative HeLa cell luciferase RNA interference mRNA splice correction assay with a functional luciferase readout, we demonstrate that parameters such as peptide nucleic acid (PNA ...Author: Mette Joergensen, Birgit Agerholm-Larsen, Peter E. Nielsen, Julie Gehl
https://www.sciencedirect.com/science/article/pii/S1359644600003263
The design and development of antisense oligonucleotides and ribozymes for the treatment of diseases arising from genetic abnormalities has become a real possibility over the past few years. Improvements in oligonucleotide chemistry have led to the synthesis of nucleic …Author: Marcus D Hughes, Majad Hussain, Qamar Nawaz, Pakeeza Sayyed, Saghir Akhtar
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(16)30083-X.pdf
affect cellular processes, schematically illustrated in Figure 1. The most obvious approach, originally proposed by Zamecnik and Stevenson,13 is antisense binding through Watson-Crick base pairing to messenger RNA (mRNA) to block translational REVIEW Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA
https://www.researchgate.net/publication/12478486_Cellular_delivery_of_antisense_oligonucleotides
Request PDF Cellular delivery of antisense oligonucleotides Antisense oligonucleotides can be successfully employed to inhibit specifically gene expression. However, many oligonucleotide ...
https://www.tandfonline.com/doi/abs/10.4161/adna.18739
Antisense activity, and by inference cellular delivery, of unmodified antisense PNA was enhanced at least 20-fold at 6 μM upon the complexation with an equimolar amount of nonamer carrier decanoyl-CPP-PNA (Deca-cPNA1(9)-(D-Arg)8).
https://www.pnas.org/content/93/8/3176.short
Apr 16, 1996 · A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA. J G Lewis, K Y Lin, A Kothavale, W M Flanagan, M D Matteucci, R B DePrince, R A Mook, R W Hendren, R W Wagner. Proceedings of the National Academy of Sciences Apr 1996, 93 (8) 3176-3181; DOI: 10.1073/pnas.93.8.3176 .Author: J. G. Lewis, Kuei-Ying Lin, Avinash Kothavale, W. M. Flanagan, M. D. Matteucci, R. B. Deprince, R. A...
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