We have collected information about Cell-Penetrating-Peptide-Mediated Sirna Lung Delivery for you. Follow the links to find out details on Cell-Penetrating-Peptide-Mediated Sirna Lung Delivery.
https://portlandpress.com/biochemsoctrans/article/35/4/807/64207/Cell-penetrating-peptide-mediated-siRNA-lung
The therapeutic application of siRNA (short interfering RNA) shows promise as an alternative approach to small-molecule inhibitors for the treatment of human disease. However, the major obstacle to its use has been the difficulty in delivering these large anionic molecules in vivo. A potential approach to solving this problem is the chemical conjugation of siRNA to the cationic CPPs (cell ...Author: Sterghios A. Moschos, Andrew E. Williams, Mark A. Lindsay
https://www.researchgate.net/publication/6203575_Cell-penetrating-peptide-mediated_siRNA_lung_delivery
A potential approach to solving this problem is the chemical conjugation of siRNA to the cationic CPPs (cell-penetrating peptides), Tat-(48-60) (transactivator of transcription) and penetratin,...
https://westminsterresearch.westminster.ac.uk/item/91q22/cell-penetrating-peptide-mediated-sirna-lung-delivery
A potential approach to solving this problem is the chemical conjugation of siRNA to the cationic CPPs (cell-penetrating peptides), Tat-(48–60) (transactivator of transcription) and penetratin, which have been shown previously to mediate protein and peptide delivery in a host of animal models.Author: Sterghios A. Moschos, Andrew E. Williams, Mark A. Lindsay
https://core.ac.uk/display/96780852
A potential approach to solving this problem is the chemical conjugation of siRNA to the cationic CPPs (cell-penetrating peptides), Tat-(48-60) (transactivator of transcription) and penetratin, which have been shown previously to mediate protein and peptide delivery in a host of animal models.
https://www.sciencedirect.com/science/article/pii/S0022354917303465
Liposomes modified with GALA/Chol (GALA/Chol-LPs) might mimic an influenza virus which could permit patterns of sialic acid–terminated sugar chains on the surfaces of the endothelial cell to be recognized. 21 In fact, competition between the uptake of GALA/Chol-LPs and free-GALA/Chol was previously examined in human lung microvascular endothelial cells (HMVEC-L). 21 Furthermore, because of …Author: Sarochin Santiwarangkool, Hidekata Akita, Hidekata Akita, Taichi Nakatani, Kenji Kusumoto, Hiroki Ki...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160355/
Aug 30, 2014 · Local delivery of siRNA into the lung, however, allows for noninvasive access and avoids interactions with serum proteins that degrade siRNA after i.v. administration. However, serum is absent on the air-side of the lung, and nuclease activity is comparably low [10].Author: Olivia M. Merkel, Israel Rubinstein, Thomas Kissel
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(10)00141-0
Nov 01, 2010 · An interesting approach for targeted delivery of siRNA has been develope, in which a CPP and a short peptide derived from rabies virus glycoprotein (RVG) is fused to a therapeutic siRNA. RVG targets acetylcholine receptors expressed in neuronal tissue and, by exploiting this feature, the siRNA induced specific gene silencing within the brainAuthor: Peter Järver, Imre Mäger, Imre Mäger, Ülo Langel, Ülo Langel
https://www.nature.com/articles/s41598-017-00662-2
Apr 06, 2017 · The inhibition of ENaC may have therapeutic potential in CF airways by reducing sodium hyperabsorption, restoring lung epithelial surface fluid levels, airway hydration and mucociliary function. The challenge has been to deliver siRNA to the lung with sufficient efficacy for a sustained therapeutic effect.Author: Maria D. I. Manunta, Aristides D. Tagalakis, Martin Attwood, Ahmad M. Aldossary, Josephine L. Barnes...
https://www.sciencedirect.com/science/article/pii/S1471489208000593
Further formulation optimization is probably required before chitosan can be considered a robust formulation for siRNA lung delivery. A third approach involves the use of cationic cell penetrating peptides (CPPs) such as Tat to mediate siRNA delivery across the cellular membrane.Author: Antonin de Fougerolles, Tatiana Novobrantseva
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)32258-4.pdf
of targeted delivery of siRNA-based therapeutics in vivo. Efficient silencing of CD47 in tumor tissues with systemic administration of LPH(CD47) also significantly inhibited the growth of melanoma tumors. In a lung metastasis model, LPH(CD47) efficiently inhibited lung metastasis to about 27% of the untreated control. Moreover, noFile Size: 2MB
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