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https://www.researchgate.net/publication/6203575_Cell-penetrating-peptide-mediated_siRNA_lung_delivery
Cell-penetrating-peptide-mediated siRNA lung delivery. ... mRNA in mouse lung in vivo. Significantly, we will also discuss potential non-specific actions and the induction of immunological ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032848/
Dec 17, 2013 · Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA. ... Plasmid-mediated delivery of these components into cells can result in uncontrolled integration of the plasmid sequence into the host genome, and unwanted immune responses and potential safety problems that can be caused by the bacterial sequences ...Author: Suresh Ramakrishna, Abu-Bonsrah Kwaku Dad, Jagadish Beloor, Ramu Gopalappa, Sang-Kyung Lee, Hyongbum...
https://portlandpress.com/biochemsoctrans/article/35/4/807/64207/Cell-penetrating-peptide-mediated-siRNA-lung
The therapeutic application of siRNA (short interfering RNA) shows promise as an alternative approach to small-molecule inhibitors for the treatment of human disease. However, the major obstacle to its use has been the difficulty in delivering these large anionic molecules in vivo. A potential approach to solving this problem is the chemical conjugation of siRNA to the cationic CPPs (cell ...Author: Sterghios A. Moschos, Andrew E. Williams, Mark A. Lindsay
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896395/
Jan 20, 2014 · Transfection of TALEN-encoding plasmid DNA or mRNA offers an alternative to viral-based methods, but these approaches are restricted to certain cell types and can be highly toxic . We previously showed that direct delivery of ZFN proteins yields highly efficient gene knockout in a variety of mammalian cell types .Author: Jia Liu, Thomas Gaj, James T. Patterson, Shannon J. Sirk, Carlos F. Barbas
https://westminsterresearch.westminster.ac.uk/item/91q22/cell-penetrating-peptide-mediated-sirna-lung-delivery
Title: Cell-penetrating-peptide-mediated siRNA lung delivery: Authors: Moschos, S.A., Williams, A.E. and Lindsay, M.A. Abstract: The therapeutic application of siRNA (short interfering RNA) shows promise as an alternative approach to small-molecule inhibitors for the treatment of human disease.Author: Sterghios A. Moschos, Andrew E. Williams, Mark A. Lindsay
https://www.sciencedirect.com/science/article/pii/S0168365912000697
Recombinant peptide constructs for targeted cell penetrating peptide-mediated delivery. ... their application in drug delivery is limited due to lack of specificity, as they are widely distributed in most tissues following in vivo administration. In order to overcome this hurdle, a highly pH-sensitive histidine–glutamic acid (HE) copolymer ...Author: Jennica L. Zaro, Likun Fei, Wei-Chiang Shen
https://www.sciencedirect.com/science/article/pii/S0168365915302078
Among those strategies, enzyme-triggered cell penetrating peptide (CPP)-mediated systems seem to be a feasible approach. The expression level of specific enzymes like proteases, esterases or glycosidases is often higher in tumor cells than in normal tissues, and such concentration gradients can be exploited as a tool for targeted cancer therapy.Author: Huining He, Lu Sun, Junxiao Ye, Ergang Liu, Sunhui Chen, Qiuling Liang, Meong Cheol Shin, Victor C. ...
https://core.ac.uk/display/96780852
A potential approach to solving this problem is the chemical conjugation of siRNA to the cationic CPPs (cell-penetrating peptides), Tat-(48-60) (transactivator of transcription) and penetratin, which have been shown previously to mediate protein and peptide delivery in a host of animal models.
https://www.researchgate.net/publication/261328792_Gene_disruption_by_cell-penetrating_peptide-mediated_delivery_of_Cas9_protein_and_guide_RNA
Apr 02, 2014 · Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA Article (PDF Available) in Genome Research 24(6) · April 2014 with 573 Reads How we …
http://www.scripps.edu/barbas/pdf/LiuPlosOne2014.pdf
prevented their delivery into cells by space-constrained delivery vehicles such as adeno-associated virus [26,27]. Transfection of TALEN-encoding plasmid DNA or mRNA offers an alternative to viral-based methods, but these approaches are restricted to certain cell types and can be highly toxic [28].
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