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https://www.sciencedirect.com/science/article/pii/S0005273606000460
We developed a biotechnologically feasible approach for gene delivery using synthetic cationic amphipathic peptides containing a variable number of histidine residues. Gene transfer to different cell lines in vitro was achieved with an efficiency comparable to commercially available reagents.Author: Antoine Kichler, A. James Mason, Burkhard Bechinger
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751301/
Feb 09, 2007 · The use of peptides as gene delivery vectors is advantageous over other nonviral agents in that they are able to achieve all of these goals. This review will focus on the application of peptides to mediate nonviral gene delivery.Author: Molly E. Martin, Kevin G. Rice
https://www.sciencedirect.com/science/article/pii/S1359644607005028
Peptides are emerging as attractive alternatives to cationic polymers and lipids for nonviral DNA delivery. Their remarkable properties such as efficient condensation of DNA, translocation across the cellular membrane, pH-sensitive membrane disruption, and efficient targeting of attached cargoes to the nucleus make them lucrative for researchers to explore their application in DNA delivery.Author: Anita Mann, Garima Thakur, Vasundhara Shukla, Munia Ganguli
https://www.researchgate.net/publication/260395546_Efficient_in_vivo_gene_delivery_using_modified_Tat_peptide_with_cationic_lipids
Efficient in vivo gene delivery using modified Tat peptide with cationic lipids ... peptides Gene delivery ... and the simple mix of these novel peptides with DNA increased the gene transfer of ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207642/
The use of various cell-penetrating peptides (CPPs) to deliver genetic material for gene therapy applications has been a topic of interest for more than 20 years. The delivery of genetic material by using CPPs can be divided into two categories: covalently ...Author: Nabil A Alhakamy, Adane S Nigatu, Cory J Berkland, Joshua D Ramsey
https://www.liebertpub.com/doi/abs/10.1089/10430349950019101
Jul 06, 2004 · To examine the suitability of synthetic peptides as DNA-binding and-compacting agents for receptor-mediated gene delivery, we have synthesized and characterized a series of branched oligocationic peptides that differ in the number and type (lysine, arginine, ornithine) of cationic amino acids in the DNA-binding moiety.Author: Christian Plank, Mary X. Tang, Alan R. Wolfe, Francis C. Szoka
https://pubs.acs.org/doi/10.1021/mp300187t
Cationic peptide sequences, whether linear, branched, or dendritic, are widely used to condense and protect DNA in both polyplex and lipopolyplex gene delivery vectors. How these peptides behave within these particles and the consequences this has on transfection efficiency remain poorly understood. We have compared, in parallel, a complete series of cationic peptides, both branched and linear ...Author: Katharina Welser, Frederick Campbell, Laila Kudsiova, Atefeh Mohammadi, Natalie Dawson, Stephen L. H...
https://www.nature.com/articles/s41467-019-12906-y
Nov 01, 2019 · In sum, the use of PPAA as a pretreatment to facilitate the uptake of biologics represents a novel, simple approach to facilitate the intracellular delivery of cationic peptides, biomacromolecules ...Author: Brian C. Evans, R. Brock Fletcher, Kameron V. Kilchrist, Eric A. Dailing, Alvin J. Mukalel, Juan M. ...
https://www.researchgate.net/publication/5663359_Lipophilic_Peptides_for_Gene_Delivery
Lipophilic Peptides for Gene Delivery. ... As an important type of nonviral gene delivery vector, peptide-based cationic liposomes have shown many advantages over other cationic liposomes, such as ...
https://pubs.acs.org/doi/10.1021/bc990012d
To define the minimal peptide length needed for gene delivery into mammalian cells, we synthesized several peptides with shortened chain lengths from the amino-termini of the original amphiphilic peptides (46, Ac-LARL-LARL-LARL-LRAL-LRAL-LRAL-NH2, and Hel 11-7, KLLK-LLLK-LWKK-LLKL-LK), which have been known to have gene transfer abilities into cells.Author: Takuro Niidome, Keiko Takaji, Mamiko Urakawa, Naoya Ohmori, Akihiro Wada, Toshiya Hirayama, Haruhiko...
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