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https://www.researchgate.net/publication/51793165_Magnetic_targeting_strategies_in_gene_delivery
Request PDF Magnetic targeting strategies in gene delivery Gene delivery is a process of the insertion of transgenes into cells with the purpose to obtain the expression of encoded protein.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508066/
In the current study, we prepared a dendrimer-based gene vector modified by gadolinium (Gd) chelation and CPPs. We then used MRI to administer and monitor gene delivery in the tumor stroma. Our goal was to develop an imaging-guided local gene delivery strategy for PDAC to enhance the efficiency of targeted gene delivery.Author: Qingbing Wang, Jianfeng Li, Sai An, Yi Chen, Chen Jiang, Xiaolin Wang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380572/
May 02, 2012 · TARGETED DELIVERY OF CANCER GENE THERAPY. Cancer, at its foundation, can be attributed to one or more malfunctioning genes. Gene therapy offers the possibility to directly address the root cause of cancer through the upregulation or downregulation of target genes and, thus, offers a wide range of potential treatment strategies for this disease.Author: Charles Li, Linda Li, Andrew C. Keates
https://www.nature.com/articles/3301624
Feb 22, 2002 · As a model for in vivo gene delivery, we tested whether gene vectors can be targeted to a selected area of a target tissue by magnetic force and carried out transfection with the LacZ reporter ...Author: F Scherer, M Anton, U Schillinger, J Henke, C Bergemann, A Krüger, B Gänsbacher, C Plank
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659361/
The 2-source magnetic targeting strategy employed here for site-specific gene delivery to stented arteries is another important determinant of the effectiveness of the present experimental approach. The inability to target nonsuperficially located sites in humans using a single magnet as the field source remains one of the principal limitations to the clinical applicability of magnetic targeting strategies ( 40 ).Author: Michael Chorny, Ilia Fishbein, Jillian E. Tengood, Richard F. Adamo, Ivan S. Alferiev, Robert J. Lev...
https://www.thno.org/v07p0295.htm
An intravascular targeting strategy, such as the lentiviral MMB technique, may constitute a valuable tool to achieve tissue specific angiogenic therapy by targeted gene delivery of VEGF.
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