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https://www.researchgate.net/publication/7645628_Cationic_Liposomes_as_In_Vivo_Delivery_Vehicles
Cationic liposomes and cationic phospholipid complexants of polynucleotides are extensively studied (Templeton, 2003), and it has been shown that the problem of rapid clearance may be overcome, to ...
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=0929-8673&volume=10&issue=14&spage=1279
Abstract: Optimization of cationic liposomal complexes for in vivo applications is complex involving many diverse components. These components include nucleic acid purification, plasmid design, formulation of the delivery vehicle, administration route and schedule, dosing, detection of gene expression, and others.
https://www.sciencedirect.com/science/article/pii/S181808761300010X
Although cationic liposomes have the potential to deliver nucleic acids in vivo, their delivery to the specific target site remains a major challenge. To enhance the distribution of nucleic acid-bearing cationic liposomes to target tissues, researchers have modified the …Author: Gayong Shim, Mi-Gyeong Kim, Joo Yeon Park, Yu-Kyoung Oh
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770731/
Cationic liposomes, ... Used in vivo, the neutral liposomes resulted in more efficient intracellular delivery and gene silencing (Peer et al. 2008). ... Liposomes make good vehicles for delivery of therapeutic agents into skin because of associated hydrophobic lipid construction. However, many complexities are associated with designing the ...Author: Melissa A. Tran, Rebecca J. Watts, Gavin P. Robertson
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/liposomal-drug-delivery
Jan A.A.M. Kamps, Gerrit L. Scherphof, in Methods in Enzymology, 2004. Introduction. In the development of liposomal drug delivery systems, pharmacokinetics, biodistribution, and cellular uptake of such systems are major issues to be dealt with. Depending on the aim of a particular study, a variety of experimental setups and methods are available to determine the in vivo behavior of liposomes ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664963/
Dec 01, 2015 · The application of liposomes to assist drug delivery has already had a major impact on many biomedical areas. They have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo.This enables effective delivery of encapsulated compounds to target sites while …Author: Lisa Sercombe, Tejaswi Veerati, Tejaswi Veerati, Fatemeh Moheimani, Sherry Y. Wu, Anil K. Sood, Susa...
https://www.researchgate.net/publication/5593892_Delivery_Vehicles_for_Small_Interfering_RNA_In_Vivo
Delivery Vehicles for Small Interfering RNA In Vivo ... for siRNA and gene delivery are mainly made of neutral and cationic lipids. Cationic liposomes, ... of the delivery vehicles in vivo (i.eAuthor: Antonin de Fougerolles
https://www.hindawi.com/journals/jdd/2011/326497/
However, due to the fact that cationic liposomes can be inactivated in the presence of serum, are unstable upon storage, and exhibit some cytotoxicity both in vitro and in vivo, anionic liposomes have been studied as potential gene delivery vehicles [63–65].Author: Daniel A. Balazs, Wt. Godbey
https://www.nature.com/articles/3301471
Jun 22, 2001 · The synthesis of a series of novel cationic lipids through the systematic substitution of cholesterol derivatives that could greatly enhance the delivery and expression of …Author: H Gao, K M Hui
https://www.nature.com/articles/nbt.3081
Oct 30, 2014 · Efficient protein delivery using cationic lipid transfection reagents enables high efficiency protein-based genome editing in vivo and in vitro. Efficient intracellular delivery of proteins is ...Author: John A. Zuris, John A. Zuris, David B. Thompson, David B. Thompson, Yilai Shu, John P. Guilinger, Jo...
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