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https://www.researchgate.net/publication/228367679_Cationic_lipids_used_in_non-viral_gene_delivery_systems
reviews the most recent studies highlightin g cationic lipids used in nonviral gene d elivery systems. Key words: Gene therapy, non-viral, lipids, c ation, delivery systems. Table of contents
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Since the initial studies, hundreds of cationic lipids have been synthesized as candidates for non-viral gene delivery and a few made it to clinical trials [85,86]. Cationic lipids can be used to form lipoplexes by directly mixing the positively charged lipids at the physiological pH with the negatively charged DNA.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.researchgate.net/publication/236590490_Cationic_lipids_used_in_non-viral_gene_delivery_systems
Cationic liposomes are non-viral delivery systems that have been employed as potential carriers of siRNA into the target cell [3]. The use of positively charged lipids typically increases siRNA ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · INTRODUCTION. Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s).
https://www.sciencedirect.com/science/article/pii/S0001868617303871
In addition, a series of cationic lipids containing phosphate linkers have been synthesized and could be used alone as non-viral vectors for gene delivery , , , , . Le Corre et al. [166] designed and synthesized a series of cationic lipids ( 39a – 39c , Fig. 29 ), in which the phosphate functional group was used as linker to assemble on ...Author: Defu Zhi, Yuchao Bai, Jian Yang, Shaohui Cui, Yinan Zhao, Huiying Chen, Shubiao Zhang
https://www.sciencedirect.com/science/article/pii/S0168365906002045
Cationic lipids and cationic polymers are the most probable alternative to viral delivery systems and are increasingly being used in vitro and in vivo. However, in vivo nucleic acid delivery has been traditionally hindered by the toxicity associated with their formulations.Author: Hongtao Lv, Hongtao Lv, Shubiao Zhang, Bing Wang, Shaohui Cui, Jie Yan
https://link.springer.com/article/10.1023%2FA%3A1007548826495
Feb 01, 2000 · Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and safely carrythe gene into the nucleus of the desired cells. A series of chemically differentcationic polymers arecurrently being investigated for these purposes. Although many cationic polymersindeed condense DNAspontaneously, which is a requirement for gene transfer in most types of cells,the ...Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · Vectors are vehicles that ferry the genetic material into a wide variety of cells, tissues and whole organs. The optimal vector and delivery system depends on the target cells and its characteristics, duration of expression and the size of the genetic material to be incorporated in the vector [3,4].The present vectors used for gene therapy are broadly classified as Viral vectors, Non-viral ...Author: Murali Ramamoorth, Aparna Narvekar
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/gene-delivery-systems-recent-progress-in-viral-and-non-viral-therapy
Viral-mediated gene delivery systems consist of viruses that are modified to be replication-deficient, but which can deliver DNA for expression. Adenoviruses, retroviruses, and lentiviruses are used as viral gene-delivery vectors (Escors and Breckpot, 2010). Non-viral gene delivery systems were introduced as an alternative to viral-based systems.Author: Erdal Cevher, Ali Demir Sezer, Emre Şefik Çağlar
https://www.academia.edu/10089853/Cationic_lipids_used_in_non-viral_gene_delivery_systems
Cationic lipids used in non-viral gene delivery systems
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