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https://www.sciencedirect.com/science/article/pii/S0168365906002045
We evaluate the structural features of cationic compounds and discuss which groups may increase the toxicity, what kind of linkages have relatively short half-life, and how proper modifications will decrease the toxicity of cationic lipids and cationic polymers for gene delivery. 2. Cationic lipidsAuthor: Hongtao Lv, Hongtao Lv, Shubiao Zhang, Bing Wang, Shaohui Cui, Jie Yan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867951/
Cationic Lipid–Nucleic Acid Complexes for Gene Delivery and Silencing: Pathways and Mechanisms for Plasmid DNA and siRNA. ... Tranchant I, Thompson B, Nicolazzi C, Mignet N, Scherman D. Physicochemical optimisation of plasmid delivery with cationic lipids. J Gene Med. 2004; 6:S24–S35.Author: Kai K. Ewert, Alexandra Zidovska, Alexandra Zidovska, Ayesha Ahmad, Nathan F. Bouxsein, Heather M. E...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066571/
Dec 15, 2010 · Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit. The lipids used to form such lipoplexes can be cationic, anionic, neutral, or a mixture thereof. Herein physical packing parameters and specific lipids used for gene delivery will be discussed, with lipids classified according to overall charge.Author: Daniel A. Balazs, Wt. Godbey
https://www.sciencedirect.com/science/article/pii/S0001868617303871
As a sister paper, this review aims to highlight the advances in cationic lipids with different linkers for gene delivery, and provides some suggestions on the development of cationic lipids via the discussion. 2. Ether linker and ester linker. Cationic lipids containing ester or …Author: Defu Zhi, Yuchao Bai, Jian Yang, Shaohui Cui, Yinan Zhao, Huiying Chen, Shubiao Zhang
https://pubs.acs.org/doi/abs/10.1021/bc300381s
Cationic lipids are one of the most widely used nonviral vectors for gene delivery and are especially attractive because they can be easily synthesized and extensively characterized. Additionally, they can best facilitate the elucidation of structure–activity relationships by modifying each of their constituent domains. The polar hydrophilic headgroups enable the condensation of nucleic ...Author: Defu Zhi, Shubiao Zhang, Shaohui Cui, Yinan Zhao, Yinhuan Wang, Defeng Zhao
https://www.nature.com/articles/nbt.3081
Oct 30, 2014 · Efficient protein delivery using cationic lipid transfection reagents enables high efficiency protein-based genome editing in vivo and in vitro. Efficient intracellular delivery of proteins is ...Author: John A. Zuris, John A. Zuris, David B. Thompson, David B. Thompson, Yilai Shu, John P. Guilinger, Jo...
https://www.thermofisher.com/us/en/home/references/gibco-cell-culture-basics/transfection-basics/gene-delivery-technologies/cationic-lipid-mediated-delivery/how-cationic-lipid-mediated-transfection-works.html
Cationic lipid-mediated delivery is a fast, simple, and reproducible means for easily introducing DNA, RNA, siRNA, or oligonucleotides into eukaryotic cells. It allows the highly efficient transfection of a broad range of cell types, including adherent, suspension, and insect cells, as well as primary cultures.
https://www.researchgate.net/publication/8009252_The_Design_of_Cationic_Lipids_for_Gene_Delivery
Synthetic gene delivery vectors are gaining increasing importance in gene therapy as an alternative to recombinant viruses. Among the various types of non-viral vectors, cationic lipids are ...
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