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https://www.sciencedirect.com/science/article/pii/S0168365906002045
Cationic lipids used for gene therapy are composed of three basic domains: a positive charged headgroup, a hydrophobic chain, and a linker which joins the polar and non-polar regions . Fig. 1 displays the three basic domains of 1,2-dioleoyloxy-3-trimethylammonium propane (DOTAP). The polar and hydrophobic domains of cationic lipids may have dramatic effects on both transfection and toxicity ...Author: Hongtao Lv, Hongtao Lv, Shubiao Zhang, Bing Wang, Shaohui Cui, Jie Yan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867951/
Cationic Lipid–Nucleic Acid Complexes for Gene Delivery and Silencing: Pathways and Mechanisms for Plasmid DNA and siRNA Kai K. Ewert , 1 Alexandra Zidovska , 2, 3 Ayesha Ahmad , 2, 4 Nathan F. Bouxsein , 1 Heather M. Evans , 1, 5 Christopher S. McAllister , 6, …Author: Kai K. Ewert, Alexandra Zidovska, Alexandra Zidovska, Ayesha Ahmad, Nathan F. Bouxsein, Heather M. E...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066571/
Dec 15, 2010 · Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit. The lipids used to form such lipoplexes can be cationic, anionic, neutral, or a mixture thereof. Herein physical packing parameters and specific lipids used for gene delivery will be discussed, with lipids classified according to overall charge.Author: Daniel A. Balazs, Wt. Godbey
https://www.sciencedirect.com/science/article/pii/S0001868617303871
Although hundreds of cationic lipids have been developed for gene transfer, unfortunately none of the currently available lipids fulfills ideal vector properties , , , , .An ideal cationic lipid for gene delivery should be efficient and non-toxic, which is able to form highly stable particles with gene, to specifically target cells, to enhance cellular uptake and endosomal release, and to ...Author: Defu Zhi, Yuchao Bai, Jian Yang, Shaohui Cui, Yinan Zhao, Huiying Chen, Shubiao Zhang
https://pubs.acs.org/doi/abs/10.1021/bc300381s
Cationic lipids are one of the most widely used nonviral vectors for gene delivery and are especially attractive because they can be easily synthesized and extensively characterized. Additionally, they can best facilitate the elucidation of structure–activity relationships by modifying each of their constituent domains. The polar hydrophilic headgroups enable the condensation of nucleic ...Author: Defu Zhi, Shubiao Zhang, Shaohui Cui, Yinan Zhao, Yinhuan Wang, Defeng Zhao
https://www.nature.com/articles/nbt.3081
Oct 30, 2014 · Figure 5: DNA sequence specificity of Cas9-mediated endogenous gene cleavage in cultured human cells by plasmid transfection or by cationic lipid–mediated protein:sgRNA delivery using …Author: John A. Zuris, John A. Zuris, David B. Thompson, David B. Thompson, Yilai Shu, John P. Guilinger, Jo...
https://www.thermofisher.com/us/en/home/references/gibco-cell-culture-basics/transfection-basics/gene-delivery-technologies/cationic-lipid-mediated-delivery/how-cationic-lipid-mediated-transfection-works.html
Specially designed cationic lipids, such as the Invitrogen Lipofectamine Transfection Reagents, facilitate DNA and siRNA delivery into cells (Chesnoy and Huang, 2000; Hirko et al., 2003; Liu et al., 2003). The basic structure of cationic lipids consists of a positively charged head group and one or …
https://www.researchgate.net/publication/8009252_The_Design_of_Cationic_Lipids_for_Gene_Delivery
The Design of Cationic Lipids for Gene Delivery Current Pharmaceutical Design, 2005, Vol. 11, No. 3 391 REFERENCES References 128-130 are related articles recently published in
https://www.hindawi.com/journals/jdd/2011/326497/
Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit. The lipids used to form such lipoplexes can be cationic, anionic, neutral, or a mixture thereof. Herein physical packing parameters and specific lipids used for gene delivery will be discussed, with lipids classified according to overall charge.Author: Daniel A. Balazs, Wt. Godbey
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