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https://www.sciencedirect.com/science/article/pii/S0169409X11002900
5.2. Transport system-mediated drug delivery across the blood–brain barrier. The combination of endogenous transport systems present in the BBB and macromolecular conjugates or surface enhanced nano-particulate delivery systems such as liposomes, nanoparticles and supermolecular complexes has been utilised to access the brain.Author: Yan Chen, Lihong Liu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604882/
Nanotechnology approaches to crossing the blood-brain barrier and drug delivery to the CNS Gabriel A Silva 1 1 Departments of Bioengineering and Ophthalmology, and Neurosciences Program, University of California, San Diego, 9415 Campus Point Drive, La Jolla, California 92037-0946, USAAuthor: Gabriel A Silva
https://www.ncbi.nlm.nih.gov/pubmed/29067674
Delivery of Biologics Across the Blood-Brain Barrier with Molecular Trojan Horse Technology. Pardridge WM(1). Author information: (1)ArmaGen, Inc., 26679 Agoura Road, Calabasas, CA, 91302, USA. [email protected]. Biologics are potential new therapeutics for …Author: William M. Pardridge
Addressing the translational challenges of effective and safe delivery of CNS drug candidates across the Blood Brain Barrier. The Blood-Brain Barrier Delivery Summit (B3DD) is the industry’s first conference dedicated to addressing the translational challenges of effective and safe delivery of CNS drug candidates.. With an emphasis on biologics, and built with the field's leading minds from ...
https://www.tandfonline.com/doi/abs/10.1081/DDC-120001481
Jan 22, 2018 · ABSTRACTNanoparticles (NP) are solid colloidal particles ranging in size from 1 to 1000 nm that are utilized as drug delivery agents. The use of NPs to deliver drugs to the brain across the blood-brain barrier (BBB) may provide a significant advantage to current strategies. The primary advantage of NP carrier technology is that NPs mask the blood-brain barrier limiting characteristics …Author: P. R. Lockman, R. J. Mumper, M. A. Khan, D. D. Allen
The blood-brain barrier and blood-retina barrier limit drug uptake G-Technology® safely enhances brain and eye drug delivery We believe that we can transform the lives of those affected faster and more successful by combining known disease targets and compounds with established drug delivery systems united with safe targeting technology.
https://www.technologynetworks.com/neuroscience/news/the-blood-brain-barrier-now-on-a-chip-330582
Feb 11, 2020 · Nanoparticle delivery. In testing related to drug delivery, nanoparticles moved through the blood-brain-barrier after engaging endothelial cell receptors, which caused these cells to engulf the particles then transport them to what would be inside the human brain in a natural setting.
https://www.onlinelibrary.wiley.com/doi/full/10.1002/smll.201701921
A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis, brain tumors, and strokes is the blood–brain barrier (BBB). The BBB prevents the passage of certain molecules and pathogens from the circulatory system into the brain.Author: Yung-Hao Tsou, Xue-Qing Zhang, He Zhu, Sahla Syed, Xiaoyang Xu
https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2012.126
made brain-penetrating with the combined use of RMT-based delivery systems and avidin–biotin technology. Knowledge on the endogenous CMT and RMT systems expressed at the BBB enable new solutions to the problem of BBB drug transport. ... Blood–brain barrier drug delivery. Blood–brain The,
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