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https://www.slideshare.net/sagarchawan5/blood-brain-barrier-ppt
Apr 10, 2014 · Blood brain barrier ppt. 1. Blood brain barrier 2. BBB • The blood-brain barrier (BBB) is a membrane that controls the passage of substances from the blood into the central nervous system. • It is a physical barrier between the local blood vessels and most parts of the central nervous system itself, and stops many substances from travelling ...
https://www.slideshare.net/ShashankSoni/brain-targeted-drug-delivery
Mar 23, 2017 · BRAIN TARGETED DRUG DELIVERY SYSTEM: A REVIEW, World journal of pharmacy and pharmaceutical sciences, 5(6),398-414 5. BLOOD BRAIN BARRIER FUNCTIONS: STABILIZER – stabilize CNS neurons PROTECTION – from toxins, microbes (bacteria) HOLDER – hold neurotransmitter within CNS Prajapati, J., Patel H, & Agrawal, Y. K. (2012).
https://www.ncbi.nlm.nih.gov/pubmed/27020469
INTRODUCTION: There are 2 misconceptions about the cerebrospinal fluid (CSF), the blood-brain barrier (BBB), and brain drug delivery, which date back to the discovery of a barrier between blood and brain over 100 years ago. Misconception 1 is that drug distribution into CSF is a measure of BBB transport.Author: William M. Pardridge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494002/
Aug 29, 2012 · The BBB is the principal interface between blood and the ISF that bathes synaptic connections within the parenchyma of the brain. A separate barrier system in the brain is localized to the epithelial cells of the choroid plexus, which form the blood–cerebrospinal fluid (CSF) barrier (BCSFB).Author: William M Pardridge
https://link.springer.com/article/10.1007%2Fs40263-016-0405-9
Jan 18, 2017 · CNS disorders are on the rise despite advancements in our understanding of their pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the blood–brain barrier (BBB), which serves as an arduous janitor to protect the brain. Many drugs are being discovered for CNS disorders, which, however fail to enter the market because of their inability to cross the BBB. …Author: Mayur M. Patel, Bhoomika M. Patel
https://www.sciencedirect.com/science/article/pii/S0028390816303616
Drug delivery across the blood-brain-barrier (BBB) must be achieved for respective therapies. • Targeting BBB-specific receptors is promising strategy for drug delivery. • Novel BBB-specific receptors can be discovered via proteomic/transcriptomic workflow. • Receptor discovery workflow is challenging but risks can be minimized by careful ...Author: Imre Mäger, Imre Mäger, Axel H. Meyer, Jinghuan Li, Martin Lenter, Tobias Hildebrandt, German Leparc...
https://www.pharmafocusasia.com/articles/blood-brain-barrier-and-cns-drug-delivery
Blood-Brain Barrier and CNS Drug Delivery Parvin Zakeri-Milani , Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran. The central nervous system is protected by barriers which control the passage of various chemical substances and microscopic objects, thereby regulating brain homeostasis.
https://en.wikipedia.org/wiki/Nanoparticles_for_drug_delivery_to_the_brain
Nanoparticles for drug delivery to the brain is a method for transporting drug molecules across the blood–brain barrier (BBB) using nanoparticles.These drugs cross the BBB and deliver pharmaceuticals to the brain for therapeutic treatment of neurological disorders.
https://www.hindawi.com/journals/bmri/2014/869269/
W. M. Pardridge, D. Wu, and T. Sakane, “Combined use of carboxyl-directed protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain up take of brain-derived neurotrophic factor following intravenous administration,” Pharmaceutical Research, vol. …Author: Ravi Kant Upadhyay
https://www.sciencedirect.com/science/article/pii/S0168365916303236
The CNS has developed a series of barriers to protect itself from invading pathogens, neurotoxic molecules and circulating blood cells. These structures with diverse degrees of permeability include the blood–cerebrospinal fluid (CSF) barrier, the blood–brain barrier (BBB), the blood–retinal barrier and the blood–spinal cord barrier .Among these, the BBB is the most extensive and exclusive.Author: Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino
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