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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388327/
The presence of the blood-brain barrier (BBB) is a significant impediment to the delivery of therapeutic agents to the brain for treatment of brain diseases. Focused ultrasound (FUS) has been developed as a non-invasive method for transiently increasing the permeability of the BBB to promote drug delivery to targeted regions of the brain.Author: Alison Burgess, Kullervo H. Hynynen
https://www.ncbi.nlm.nih.gov/pubmed/28101766
Crossing the Blood-Brain Barrier: Recent Advances in Drug Delivery to the Brain. ... A major hurdle to the treatment of these disorders is the blood-brain barrier (BBB), which serves as an arduous janitor to protect the brain. Many drugs are being discovered for CNS disorders, which, however fail to enter the market because of their inability ...Author: Mayur M. Patel, Bhoomika M. Patel
https://link.springer.com/article/10.1007%2Fs40263-016-0405-9
Jan 18, 2017 · CNS disorders are on the rise despite advancements in our understanding of their pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the blood–brain barrier (BBB), which serves as an arduous janitor to protect the brain. Many drugs are being discovered for CNS disorders, which, however fail to enter the market because of their inability to cross the BBB. …Author: Mayur M. Patel, Bhoomika M. Patel
http://downloads.hindawi.com/journals/bmri/2014/869269.pdf
show the inability to pass through the blood brain barrier with the adhered protein. erefore, such drugs cannot be made available to the brain because they cannot be trans-ported and delivered across the blood brain barrier. Further, enzyme action also makes the drug inactive or converts it in a nontherapeutic intermediate compound. However,
https://www.researchgate.net/publication/337640026_The_blood-brain_barrier_Physiology_and_strategies_for_drug_delivery
The physiology of the vasculature in the central nervous system (CNS), which includes the blood-brain barrier (BBB) and other factors, severely limits the delivery of most drugs to the brain and ...
https://www.researchgate.net/publication/8053272_Drug_delivery_and_in_vitro_models_of_the_blood-brain_barrier
An understanding of the physiology of the blood-brain barrier (BBB) is crucial when addressing complex issues such as drug delivery, pathogenesis of chronic neurological diseases and bio-defense.
https://www.sciencedirect.com/science/article/pii/S0168365916303236
The CNS has developed a series of barriers to protect itself from invading pathogens, neurotoxic molecules and circulating blood cells. These structures with diverse degrees of permeability include the blood–cerebrospinal fluid (CSF) barrier, the blood–brain barrier (BBB), the blood–retinal barrier and the blood–spinal cord barrier .Among these, the BBB is the most extensive and exclusive.Author: Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino
https://link.springer.com/book/10.1007%2F978-1-4614-9105-7
This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB. It contains cutting-edge methods for studying …
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