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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127280/
Jul 20, 2014 · Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier. Ravi Kant Upadhyay * Author information ... Pardridge WM, Wu D, Sakane T. Combined use of carboxyl-directed protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain up take of brain-derived neurotrophic factor following intravenous ...Author: Ravi Kant Upadhyay
https://www.pharmafocusasia.com/articles/blood-brain-barrier-and-cns-drug-delivery
Blood-Brain Barrier and CNS Drug Delivery Parvin Zakeri-Milani , Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran. The central nervous system is protected by barriers which control the passage of various chemical substances and microscopic objects, thereby regulating brain homeostasis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604882/
Nanotechnology approaches to crossing the blood-brain barrier and drug delivery to the CNS Gabriel A Silva 1 1 Departments of Bioengineering and Ophthalmology, and Neurosciences Program, University of California, San Diego, 9415 Campus Point Drive, La Jolla, California 92037-0946, USAAuthor: Gabriel A Silva
https://www.hindawi.com/journals/bmri/2014/869269/
Present review highlights various drug delivery systems used for delivery of pharmaceutical agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic substances through the endothelial capillaries (BBB) for CNS therapeutics. In addition, the use of ultrasound in delivery of therapeutic agents/biomolecules such as proline rich peptides, prodrugs ...Author: Ravi Kant Upadhyay
https://www.nature.com/articles/nrd.2015.21
Jan 22, 2016 · Research on the blood–brain barrier (BBB) has led to the concept of a complex, dynamic interface between the central nervous system (CNS) and periphery. Banks considers how this new ...Author: William A. Banks
https://www.sciencedirect.com/science/article/pii/S0169409X11002900
5.2. Transport system-mediated drug delivery across the blood–brain barrier. The combination of endogenous transport systems present in the BBB and macromolecular conjugates or surface enhanced nano-particulate delivery systems such as liposomes, nanoparticles and supermolecular complexes has been utilised to access the brain.Author: Yan Chen, Lihong Liu
Addressing the translational challenges of effective and safe delivery of CNS drug candidates across the Blood Brain Barrier. The Blood-Brain Barrier Delivery Summit (B3DD) is the industry’s first conference dedicated to addressing the translational challenges of effective and safe delivery of CNS drug candidates.. With an emphasis on biologics, and built with the field's leading minds from ...
https://link.springer.com/article/10.1007%2Fs40263-016-0405-9
Jan 18, 2017 · CNS disorders are on the rise despite advancements in our understanding of their pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the blood–brain barrier (BBB), which serves as an arduous janitor to protect the brain. Many drugs are being discovered for CNS disorders, which, however fail to enter the market because of their inability to cross the BBB. …Author: Mayur M. Patel, Bhoomika M. Patel
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