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https://www.researchgate.net/publication/26576955_Bioavailability_of_intranasal_drug_delivery_system
Despite of all the advantages of nasal drug delivery, the bioavailability of nasally administered products, especially for protein and peptide molecules, is affected by many barriers such as ...
https://www.asiapharmaceutics.info/index.php/ajp/article/viewFile/203/152
Bioavailability of intranasal drug delivery system Satish Balakrishna Bhise, Adhikrao Vyankatrao Yadav, Amelia Makrand Avachat, Rajkumar Malayandi Biopharmaceutical Research Group, Department of Biopharmaceutics, Government College of Pharmacy, Karad, India N
https://www.sciencedirect.com/science/article/pii/S0361923018303678
Targeted nano-drug delivery systems conjugated with specific ligands could enhance the efficacy of drug delivery. Most transporters have a site-specific expression, which provide ideal targets for drug delivery to increase uptake at specific site or enhance permeation across biological barriers such as the blood–brain barrier.Author: Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, Sveinbjörn Gizurarson
https://www.researchgate.net/publication/232805466_ENHANCED_BIOAVAILABILITY_OF_DRUGS_VIA_INTRANASAL_DRUG_DELIVEY_SYSTEM
The aim of present investigation is to explain the enhancement of bioavailability of drug through intranasal drug delivery system. Intranasal Therapy has been an accepted form of treatment in the ...
https://www.medicinalgenomics.com/wp-content/uploads/2011/12/Transdermal_CBD.pdf
Intranasal and transdermal delivery of cannabidiol 1089 Oral bioavailability of CBD is low and ranges from 6% to 33% in humans and dogs, respectively7–9; hence the oral route is not ideal for the therapeutic delivery of CBD. As the drug has low aqueous solubility and under-goes first-pass metabolism, alternative delivery routes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease Leah R Hanson 1 and William H Frey, II 1, 2 1 Alzheimer's Research Center at Regions Hospital, HealthPartners Research Foundation, 640 Jackson Street, St. Paul, Minnesota 55101, USAAuthor: Leah R Hanson, William H Frey, William H Frey
http://intranasal.net/Overview/default.htm
Finally, if the drug concentration is such that it can be delivered in a reasonable volume to the nose so no runoff into the throat or out the nostril occurs, then more absorption and higher bioavailability is possible. In general the ideal volume for one nostril is about 0.25 to 0.3 ml,...
https://www.slideshare.net/kawii/nasal-drug-delivery-system-41893460
Nov 22, 2014 · Intranasal Medication administration offers a truly “Needleless ” solution to drug delivery. In recent years many drugs have been shown to achieve better systemic bioavailability through nasal route than by oral administration JNTUH,CPS,13031S0304 3.
http://japer.sperpublications.com/oldjaper/Issue/issues%204oct-des%202013/148.pdf
Limitations of nasal drug delivery system • Delivery volume in nasal cavity is restricted to 25–200 μL. • High molecular weight compounds cannot be delivered through this route (mass cut off ~1 kDa). • Adversely affected by pathological conditions. • Large interspecies variability is observed in this route.File Size: 845KB
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