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https://www.nature.com/articles/nature18915
Jul 20, 2016 · Regardless, the new bacteria are notably different from the conventional ones. First, drug delivery is achieved through the simultaneous lysis of the entire population, rather than through continuous secretion by proliferating individuals. Second, the periodic lysis serves as …Author: Shibin Zhou
https://www.sciencedaily.com/releases/2018/12/181220122606.htm
Dec 20, 2018 · Bacteria-based drug delivery system that outperforms conventional methods Using salmonella for good. Humans have noticed, even as far back as Ancient Egypt, that cancer went into remission if the patient also contracted an infection like salmonella. Trial and error. Although Behkam had a …
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Other NIBIB-funded researchers are developing a system of drug delivery using a type of bacteria that has a two-part navigation system—magnetic and oxygen sensing. They have tested the delivery system in mice, achieving a remarkable success delivering drugs to tumors. The bacteria seek out oxygen-poor zones, which are a feature of tumors.
https://phys.org/news/2018-12-bacteria-based-drug-delivery-outperforms-conventional.html
Dec 20, 2018 · The new system created at Virginia Tech is known as Nanoscale Bacteria-Enabled Autonomous Drug Delivery System (NanoBEADS). Researchers have developed a process to chemically attach nanoparticles of anti-cancer drugs onto attenuated bacteria cells,...
https://www.sciencedirect.com/science/article/pii/S0016508500702885
The appeal includes both the beneficial use of bacteria, which has been previously established through treatments with probiotics (Gionchetti et al., Gastroenterology 2000;119:305-309), as well as the inexpensive and local delivery of an effective cytokine.Author: Dan Gordon
http://sitn.hms.harvard.edu/flash/2017/microbial-physicians-delivering-drugs-bacteria/
Mar 17, 2017 · Ultimately, genetically modified bacteria are self-propelling drug factories, making them attractive vehicles for drug delivery. In addition to their ability to secrete therapeutics, the bacteria themselves exert beneficial effects: ranging from bacteria known to be good for health (probiotics), to the selective toxicity of Salmonella towards cancer cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572107/
May 03, 2019 · The most common virus-based drug delivery platforms are based on chemotherapeutics, and the viral particles are employed as carriers for small drug molecules. In this manner, doxorubicin, which is a clinically approved anticancer agent, has been extensively studied.Author: Esen Sokullu, Hoda Soleymani Abyaneh, Marc A. Gauthier
https://www.nature.com/articles/s41598-017-02591-6
May 23, 2017 · The use of live, genetically modified bacteria as delivery vehicles for biologics is of considerable interest scientifically and has attracted significant commercial investment. We have pioneered the use of the commensal gut bacterium Bacteroides ovatus for the oral delivery of therapeutics to the gastrointestinal tract.Author: Udo Wegmann, Ana Lucia Carvalho, Ana Lucia Carvalho, Martin Stocks, Simon R. Carding, Simon R. Cardi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410909/
Apr 17, 2015 · Synthetic Microbes As Drug Delivery Systems Jan Claesen and Michael A. Fischbach * Department of Bioengineering and Therapeutic Sciences and the California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, California 94158, United StatesAuthor: Jan Claesen, Michael A. Fischbach
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