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https://www.nature.com/articles/nature18915
Jul 20, 2016 · Regardless, the new bacteria are notably different from the conventional ones. First, drug delivery is achieved through the simultaneous lysis of the entire population, rather than through continuous secretion by proliferating individuals. Second, the periodic lysis serves as …Author: Shibin Zhou
https://www.gastrojournal.org/article/S0016-5085(00)70288-5/fulltext
The authors hypothesized that the mechanism of delivery of the IL-10 might be either by its secretion into the intestinal lumen, or by uptake of the genetically engineered bacteria by M cells with production within the intestinal lymphoid tissue.Author: Dan Gordon
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Other NIBIB-funded researchers are developing a system of drug delivery using a type of bacteria that has a two-part navigation system—magnetic and oxygen sensing. They have tested the delivery system in mice, achieving a remarkable success delivering drugs to tumors. The bacteria seek out oxygen-poor zones, which are a feature of tumors.
https://www.sciencedirect.com/science/article/pii/S0016508500702885
Gastroenterology News. Bacteria as drug delivery systems. Inflammatory bowel diseases are characterized by chronic, relapsing inflammation of the small intestine or colon. These disorders appear to represent an inappropriate cellular immune response to normal enteric flora in …Author: Dan Gordon
https://phys.org/news/2018-12-bacteria-based-drug-delivery-outperforms-conventional.html
Dec 20, 2018 · The new system created at Virginia Tech is known as Nanoscale Bacteria-Enabled Autonomous Drug Delivery System (NanoBEADS). Researchers have developed a process to chemically attach nanoparticles of anti-cancer drugs onto attenuated bacteria cells,...
https://nutritionreview.org/2019/01/bacterial-based-cancer-drug-delivery-system-outperforms-conventional-methods/
Jan 02, 2019 · The new system, known as Nanoscale Bacteria-Enabled Autonomous Drug Delivery System (NanoBEADS), chemically attaches nanoparticles of anti-cancer drugs onto attenuated (weakened) bacteria cells, which have been shown to be significantly more effective than traditional injections at reaching cancer sites.
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