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https://www.sciencedirect.com/science/article/pii/S0169409X04002133
Jan 10, 2005 · The latter property has obvious advantages for manufacture, cost, delivery and ease of registration. ISCOMATRIX® adjuvant also demonstrates significant potential as a mucosal adjuvant, particularly for intranasal administration. Manufacture of the ISCOMATRIX® adjuvant is simple, robust and reproducible and can be performed at large scale.Author: Martin J. Pearse, Debbie Drane
https://www.sciencedirect.com/science/article/abs/pii/S0169409X04002133
The ability of the ISCOMATRIX® adjuvant to induce these broad immune responses is due to the combination of antigen presentation by both MHC class I and class II pathways, and the powerful immunomodulatory capability of the saponin.Author: Martin J. Pearse, Debbie Drane
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285562/
Jul 01, 2011 · In conclusion, ISCOMATRIX adjuvant combines characteristics of a potent immune modifier with effective Ag delivery to DCs in vivo and leads to the induction of a strong cellular immune response. ISCOMATRIX adjuvant-based vaccines have shown promising results in patients with cancer . The data presented in this study support our understanding of ...Author: Peter Duewell, Ulrich Kisser, Klaus Heckelsmiller, Sabine Hoves, Patrizia Stoitzner, Sandra Koernig,...
https://www.researchgate.net/publication/8166300_ISCOMATRIX_adjuvant_for_antigen_delivery
ISCOMATRIX adjuvant for antigen delivery. ... The ability of the ISCOMATRIX adjuvant to induce these broad immune responses is due to the combination of antigen presentation by both MHC class I ...
https://www.ncbi.nlm.nih.gov/pubmed/15560952
Jan 10, 2005 · ISCOMATRIX adjuvant for antigen delivery. ... The ability of the ISCOMATRIX adjuvant to induce these broad immune responses is due to the combination of antigen presentation by both MHC class I and class II pathways, and the powerful immunomodulatory capability of the saponin. Additionally, the ISCOMATRIX adjuvant is simple to manufacture and ...Author: Martin J. Pearse, Debbie Drane
https://www.deepdyve.com/lp/elsevier/iscomatrix-adjuvant-for-antigen-delivery-8Kgu7U1wHm
Jan 10, 2005 · Read "ISCOMATRIX® adjuvant for antigen delivery, Advanced Drug Delivery Reviews" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.researchgate.net/publication/51166251_ISCOMATRIX_Adjuvant_Combines_Immune_Activation_with_Antigen_Delivery_to_Dendritic_Cells_In_Vivo_Leading_to_Effective_Cross-Priming_of_CD8_T_Cells
ISCOMATRIX Adjuvant Combines Immune Activation with Antigen Delivery to Dendritic Cells In Vivo Leading to Effective Cross-Priming of CD8+ T Cells ... or ISCOMATRIX adjuvant alone and VDLNs were ...
https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.040857-0
The ISCOMATRIX adjuvant has antigen delivery and presentation properties as well as immunomodulatory capabilities, which combine to provide enhanced and accelerated immune responses. The responses are broad, including a range of subclasses of antibodies as well as CD4+ and CD8+ T-cells. A range of ISCOMATRIX vaccines (ISCOMATRIX adjuvant combined with antigen) have now …Author: Adriana Baz Morelli, Dorit Becher, Sandra Koernig, Anabel Silva, Debbie Drane, Eugene Maraskovsky
https://www.nature.com/articles/mi200859
Sep 24, 2008 · Requirement for both the pulmonary route of delivery and adjuvant for potent immune response to low antigen dose influenza immunization. We …Author: J L J Wee, J-P Y Scheerlinck, K J Snibson, S Edwards, M Pearse, C Quinn, P Sutton
http://europepmc.org/abstract/MED/15560952
Feb 01, 2005 · These studies have shown that the ISCOMATRIX adjuvant is safe and induces both humoral and cellular immune responses. The ability of the ISCOMATRIX adjuvant to induce these broad immune responses is due to the combination of antigen presentation by both MHC class I and class II pathways, and the powerful immunomodulatory capability of the saponin.Author: Martin J. Pearse, Debbie Drane
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