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https://www.oligotherapeutics.org/targeted-delivery-using-aptamers/
July 25, 2019Currently, effective cell-targeted delivery tools for oligonucleotide therapeutics are limited. Aptamers that internalize into target cells have been shown to deliver a wide variety of nucleic acid therapeutics, from siRNAs (
https://www.sciencedirect.com/science/article/pii/S0142961217305781
The aptamer-functionalized PPC lipopolymer could be a promising in vivo tumor-targeted delivery system for therapeutic CRISPR/Cas9. This work may pave the road for new clinical approaches using CRISPR/Cas9 in cancer treatment. Competing interests statementsAuthor: Chao Liang, Fangfei Li, Luyao Wang, Zong-Kang Zhang, Chao Wang, Bing He, Jie Li, Zhihao Chen, Atik B...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
The sgc8c aptamer is therefore a promising candidate for targeted drug delivery. Huang et al. [ 38 ] covalently conjugated the anthracycline chemotherapeutic agent doxorubicin (Dox) to the sgc8c aptamer using an acid-labile hydrazone linkage.Author: Partha Ray, Rebekah R. White
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089008/
May 06, 2014 · With the goal of utilizing aptamers for targeted antigen delivery, we have identified aptamers that recognize the murine receptor DEC205 (mDEC205) and have subsequently adapted them for use as a targeted antigen delivery agent. DEC205 …Author: Brian C Wengerter, Joseph A Katakowski, Jacob M Rosenberg, Jacob M Rosenberg, Chae Gyu Park, Chae Gy...
https://pubs.acs.org/doi/pdf/10.1021/mp500047b
Aptamer-Targeted DNA Nanostructures for Therapeutic Delivery Phapanin Charoenphol and Harry Bermudez* Department of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003, United States *S Supporting Information ABSTRACT: DNA-based nanostructures have been widely used in various applications due to their ...
https://www.sciencedirect.com/science/article/pii/S0169409X1830200X
Towards this end, aptamer-nanocarrier conjugates have been extensively explored for targeted drug delivery, based on nanoplatforms such as liposomes, DNA/RNA nanostructures, and inorganic gold or silicon nanomaterials [, , ] (Fig. 3D).Author: Guizhi Zhu, Xiaoyuan Chen
https://pubs.acs.org/doi/10.1021/nn901374b
Aptamer-guided upconversion nanoplatform for targeted drug delivery and near-infrared light-triggered photodynamic therapy. Journal of Biomaterials Applications 2020 , 34 (6) , 875-888.Author: Yen-An Shieh, Shu-Jyuan Yang, Ming-Feng Wei, Ming-Jium Shieh
https://www.intechopen.com/online-first/aptamers-for-targeted-delivery-current-challenges-and-future-opportunities
Due to this, a number of aptamers are entering clinical trials. In summary, aptamer-mediated targeted delivery remains a work in progress; however, with bright results at in vivo level and several aptamer drugs in clinical trials, the coming decade will determine their efficiency at the clinical level.Author: Chetan Chandola, Muniasamy Neerathilingam
https://www.nature.com/articles/nrd.2016.199
Nov 03, 2016 · In addition, many aptamers are internalized upon binding to cellular receptors, making them useful targeted delivery agents for small interfering RNAs …Author: Jiehua Zhou, John Rossi
http://cancerres.aacrjournals.org/content/78/3/798
Feb 01, 2018 · Second, the preparation procedure for current ENV-based targeted drug delivery systems is tedious and labor-intensive. The typical approach is to secrete targeting peptide- or protein-grafted ENVs by transfecting the donor cells with corresponding recombinant virus or plasmid .Author: Yuan Wan, Lixue Wang, Lixue Wang, Chuandong Zhu, Qin Zheng, Guoxiang Wang, Jinlong Tong, Yuan Fang, ...
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