We have collected information about Aptamer Sirna Delivery for you. Follow the links to find out details on Aptamer Sirna Delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474074/
For aptamer-mediated siRNA delivery, aptamer:streptavidin:siRNA conjugates were added directly to the media (500 µl) at a final concentration of 45 nM siRNA or 22.5 nM conjugate (average of 2 siRNAs/conjugate). Cells were harvested 72 h after the addition of the conjugate and monitored for gene expression inhibition by real-time PCR.Author: Ted C. Chu, Karen Y. Twu, Andrew D. Ellington, Matthew Levy
https://www.aptamergroup.co.uk/sirna-delivery/
The data shows that the aptamer successfully delivers the construct to the target cells. Once the siRNA has been internalised and processed, the siRNA target proteins are depleted, and cell death occurs. Importantly the aptamer portion of the chimera ensures that only cells which express PSMA are …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692808/
Aug 14, 2019 · The stability and tissue-specific delivery of siRNA remain as the biggest obstacles for RNAi therapeutics. Here, deoxynucleotide-substituted siRNA is used to improve stability of siRNA, and GS core was further coated with AS1411 aptamer for tumor targeting and disulfide linker for redox-responsive delivery of siRNA.Author: Xueqin Zhao, Yinyin Xi, Yongming Zhang, Qiuyan Wu, Ruiyuan Meng, Bin Zheng, Lei Rei
https://www.sciencedirect.com/science/article/pii/S0378517317302740
In that study, the authors presented a mechanism of siRNA delivery by aptamers specific for the PSMA receptor that occurs in two steps. The first step is characterized by the delivery of the chimeric aptamer attached non-covalently to nanoparticles that have the ability …Author: Carlos E.B. de Almeida, Lais Nascimento Alves, Henrique F. Rocha, Januário Bispo Cabral-Neto, Sotiri...
https://www.gene-quantification.de/mcnamara-sirna-2006.pdf
Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras James O McNamara II1,3, Eran R Andrechek2,3, Yong Wang1, Kristi D Viles1, Rachel E Rempel2, Eli Gilboa1, Bruce A Sullenger1 & Paloma H Giangrande1 Technologies that mediate targeted delivery of small interfering RNAs (siRNAs) are needed to improve their therapeutic efficacy
https://www.idtdna.com/pages/education/decoded/article/-em-in-vivo-em-delivery-of-aptamer-dsirna-molecules-targeting-hiv-1
Mar 29, 2013 · In this article, the researchers describe a modification to the aptamer–siRNA molecule that creates an aptamer–bridge construct and improves the utility of aptamers as siRNA delivery vehicles. The aptamer specific to HIV-1 gp120 (anti-gp120 aptamer) was synthesized with a 3’ 7-carbon linker, which was attached to a 16-nt, 2’-O-methyl/2 ...
https://onlinelibrary.wiley.com/doi/full/10.1002/wnan.1543
In this review, we summarize recent advances in developing aptamer‐mediated siRNA delivery systems for RNAi therapeutics, mainly aptamer–siRNA chimeras and aptamer‐functionalized nanocarriers incorporating siRNA, with a focus on their molecular designs and formulations.Author: Padmanaban Sivakumar, Sumin Kim, Han Chang Kang, Min Suk Shim
https://www.nature.com/articles/nbt1223
Jun 25, 2006 · Technologies that mediate targeted delivery of small interfering RNAs (siRNAs) are needed to improve their therapeutic efficacy and safety. Therefore, we have developed aptamer-siRNA chimeric RNAs ...Author: James O McNamara, Eran R Andrechek, Yong Wang, Kristi D Viles, Rachel E Rempel, Eli Gilboa, Bruce A ...
https://pubs.rsc.org/en/content/articlelanding/2013/sc/c3sc51538a
A new multifunctional probe comprising a cell-specific internalization aptamer, fluorescent silver nanoclusters (Ag NCs), and therapeutic siRNA was developed in one system for the specific delivery of siRNA into a target cell and for simultaneous noninvasive imaging.Author: Jingjing Li, Jingjing Li, Wenjing Wang, Defang Sun, Jiangning Chen, Peng-Hui Zhang, Jian-Rong Zhang,...
Searching for Aptamer Sirna Delivery?
You can just click the links above. The data is collected for you.
