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https://www.researchgate.net/publication/267365884_Aptamer-Nanoparticle_Bioconjugates_for_Drug_Delivery
The main focus will be on aptamer-incorporated nanoparticle systems for drug delivery purposes in order to assess the future potential of aptamers in the therapeutic area.
https://www.ncbi.nlm.nih.gov/pubmed/16640493
Drug-encapsulated polymeric nanoparticle-aptamer bioconjugates represent an emerging technology that can facilitate the delivery of chemotherapeutics to primary and metastatic tumours. Aptamers are short nucleic acid molecules with binding properties and biochemical characteristics that may make them suitable for use as targeting molecules.Author: Omid C Farokhzad, Jeffrey M Karp, Robert Langer
https://www.ncbi.nlm.nih.gov/pubmed/15520166
Nov 01, 2004 · Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells. Farokhzad OC(1), Jon S, Khademhosseini A, Tran TN, Lavan DA, Langer R. Author information: (1)Department of Anesthesiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.Author: Omid C. Farokhzad, Sangyong Jon, Ali Khademhosseini, Thanh-Nga T. Tran, David A. LaVan, Robert Lange...
https://cdn.intechopen.com/pdfs/36881/InTech-Aptamer_nanoparticle_bioconjugates_for_drug_delivery.pdf
Aptamer-Nanoparticle Bioconjugates for Drug Delivery 135 2.2 Aptamers selected for whole cells (cell-Selex) Cell specific aptamers can also be selected by using whole cells as target. Instead of se lecting for a purified and defined target, aptamers can be selected by subtracting the background
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024077
MUC1 protein is an attractive target for anticancer drug delivery owing to its overexpression in most adenocarcinomas. In this study, a reported MUC1 protein aptamer is exploited as the targeting agent of a nanoparticle-based drug delivery system. Paclitaxel (PTX) loaded poly (lactic-co-glycolic-acid) (PLGA) nanoparticles were formulated by an emulsion/evaporation method, and MUC1 aptamers ...
https://www.researchgate.net/profile/Veli_Ozalp/publication/267365884_Aptamer-Nanoparticle_Bioconjugates_for_Drug_Delivery/links/5458c3180cf2bccc4912a110.pdf
Aptamer-Nanoparticle Bioconjugates for Drug Delivery 135 2.2 Aptamers selected for whole cells (cell-Selex) Cell specific aptamers can also be selected by using whole cells as target.
https://cancerres.aacrjournals.org/content/64/21/7668
Nov 01, 2004 · In contrast to LNCaP cells, the uptake of these particles is not enhanced in cells that do not express the prostate-specific membrane antigen protein. To our knowledge, this represents the first report of targeted drug delivery with nanoparticle-aptamer bioconjugates.Author: Omid C. Farokhzad, Sangyong Jon, Ali Khademhosseini, Thanh-Nga T. Tran, David A. LaVan, Robert Lange...
https://link.springer.com/article/10.2165/00137696-200604030-00001
Aug 20, 2012 · As novel drug delivery vehicles, nanoparticle-aptamer bioconjugates may be developed to target a myriad of diseases including many cancers by delivering a variety of therapeutic agents specifically to the site of interest.Author: Benjamin A. Teply, Benjamin A. Teply, Benjamin A. Teply, Flavio G. Rocha, Etgar Levy-Nissenbaum, Etg...
https://phys.org/news/2005-11-drug-delivery-nanoparticle-aptamer-bioconjugates.html
Nov 01, 2005 · These results mark the first ever example of targeted drug delivery using nanoparticle-aptamer bioconjugates. Significantly, the drug delivery was highly specific.
https://www.biologyonline.com/articles/targeted-drug-delivery-achieved
Nov 18, 2007 · These results mark the first ever example of targeted drug delivery using nanoparticle-aptamer bioconjugates. Significantly, the drug delivery was highly specific. Uptake of particles was not seen to be enhanced in cells which did not express the PSMA protein, indicating a …
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