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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474074/
For aptamer-mediated siRNA delivery, aptamer:streptavidin:siRNA conjugates were added directly to the media (500 µl) at a final concentration of 45 nM siRNA or 22.5 nM conjugate (average of 2 siRNAs/conjugate). Cells were harvested 72 h after the addition of the conjugate and monitored for gene expression inhibition by real-time PCR.Author: Ted C. Chu, Karen Y. Twu, Andrew D. Ellington, Matthew Levy
https://www.researchgate.net/publication/7041705_Aptamer_mediated_siRNA_delivery
Paralleling these efforts, an elegant approach for aptamer-mediated siRNA delivery was developed by Chu et al. in 2006 in which streptavidin served as a tetravalent core to connect two identical ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238741/
Aptamer-siRNA delivery. To-date, the use of synthetic siRNAs has been largely adopted to suppress the expression of pathologically important genes in cancer and several preclinical studies have shown the effective inhibition of tumor cell growth, angiogenesis, metastasis and chemo-resistance (Bora et al, 2012; Rao et al, 2013).Given the unprecedented potential impact in using si/miRNAs for ...Author: Carla Lucia Esposito, Silvia Catuogno, Vittorio de Franciscis
https://pubs.rsc.org/en/content/articlelanding/2013/sc/c3sc51538a
A new multifunctional probe comprising a cell-specific internalization aptamer, fluorescent silver nanoclusters (Ag NCs), and therapeutic siRNA was developed in one system for the specific delivery of siRNA into a target cell and for simultaneous noninvasive imaging.Author: Jingjing Li, Jingjing Li, Wenjing Wang, Defang Sun, Jiangning Chen, Peng-Hui Zhang, Jian-Rong Zhang,...
https://onlinelibrary.wiley.com/doi/full/10.1002/wnan.1543
To date, various aptamer‐mediated siRNA delivery systems have been developed to enhance the RNA interference (RNAi) efficacy of siRNA via targeted delivery. In this review, we summarize recent advances in developing aptamer‐mediated siRNA delivery systems for RNAi therapeutics, mainly aptamer–siRNA chimeras and aptamer‐functionalized ...Author: Padmanaban Sivakumar, Sumin Kim, Han Chang Kang, Min Suk Shim
https://www.alliedacademies.org/articles/aptamermediated-selective-delivery-of-short-rna-therapeutics-in-cancer-cells.html
Aptamer mediated siRNA delivery. Nucleic Acids Res, 34, e73. Dai F, Zhang Y, Zhu X, Shan N, Chen Y. 2012. Anticancer role of MUC1aptamer-miR-29b chimera in epithelial ovarian carcinoma cells through regulation of PTEN methylation. Target Oncol, 7, 217–225. Dassie JP, Liu XY, Thomas GS et al. 2009. Systemic administration of optimized aptamer ...Author: Carla Lucia Esposito, Silvia Catuogno, Vittorio de Franciscis
https://www.researchgate.net/publication/302212425_Aptamer-Mediated_siRNA_Targeting
Request PDF Aptamer-Mediated siRNA Targeting RNA interference (RNAi) is a sequence-specific mechanism for posttranscriptional inhibition of gene expression. As such, it is an attractive ...
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-014-0108-9
Background. Epithelial cell adhesion molecule (EpCAM) is overexpressed in solid tumors and regarded as a putative cancer stem cell marker. Here, we report that employing EpCAM aptamer (EpApt) and EpCAM siRNA (SiEp) dual approach, for the targeted delivery of siRNA to EpCAM positive cancer cells, efficiently inhibits cancer cell proliferation.Author: Nithya Subramanian, Jagat R Kanwar, Prasanna kumar Athalya, Narayanan Janakiraman, Vikas Khetan, Rup...
https://link.springer.com/content/pdf/10.1186%2Fs12929-014-0108-9.pdf
RESEARCH Open Access EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex Nithya Subramanian1,2, Jagat R Kanwar2*, Prasanna kumar Athalya1,2, Narayanan Janakiraman1, Vikas Khetan4, Rupinder K Kanwar2, Sailaja Eluchuri1 and Subramanian Krishnakumar1,3* AbstractAuthor: Nithya Subramanian, Jagat R Kanwar, Prasanna kumar Athalya, Narayanan Janakiraman, Vikas Khetan, Rup...
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