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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043981/
Oct 30, 2010 · Such aptamer-mediated delivery systems are expected to achieve selective uptake into target cells, thereby minimizing unwanted side effects of the drugs in nontarget cells. The A-9 PSMA aptamer has been employed as a carrier to deliver a gelonin toxin (rGel) into PSMA receptor-expressing cells ( Fig. 1C ) (Chu et al., 2006a ).Author: Jiehua Zhou, John J. Rossi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107293/
Correspondingly, one of the most promising drug delivery strategies is aptamer-mediated nanovehicles (AMNVs). Aptamers are newly emerging small nucleic-acid ligands that target various disease markers, and they also represent an interesting class of novel pharmaceuticals due to their advantageous properties for research, diagnostics and therapeutics 12 .Author: Jie Zhu, He Huang, Shiwu Dong, Liang Ge, Yuan Zhang
https://www.mdpi.com/1424-8247/9/4/69/pdf
To date, different aptamer-drug systems and aptamer–nanoparticles systems, in which nanoparticles function together with aptamers for the targeted delivery, have been successfully developed for a wide range of therapeutics, including toxins; peptides; chemotherapeutics and oligonucleotides. Therefore, aptamer-mediated drug deliveryAuthor: Silvia Catuogno, Carla L. Esposito, Vittorio De Franciscis
https://www.ncbi.nlm.nih.gov/pubmed/27827876
Nov 03, 2016 · Aptamer-Mediated Targeted Delivery of Therapeutics: An Update. ... In this review, we will summarize recent progress in the field of aptamer-mediated drug delivery and we will discuss the advantages, the achieved objectives and the challenges to be still addressed in the near future, in order to improve the effectiveness of therapies.Author: Silvia Catuogno, Carla L. Esposito, Vittorio De Franciscis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464421/
EGFR aptamer (E07) delivers gemcitabine to MiaPaCa-2 cells and induces cell death. Gem (dFdC) is a cytotoxic nucleoside analog, and we reasoned that it could be amenable to polymerization and hybridization to the E07 aptamer for targeted delivery into the pancreatic cancer cells.Author: Partha Ray, Marcus A. Cheek, Mariam L. Sharaf, Na Li, Andrew D. Ellington, Bruce A. Sullenger, Barba...
https://www.researchgate.net/publication/307895794_Aptamer_Mediated_Niosomal_Drug_Delivery
Therefore, aptamers can be served as ideal targeting ligands for drug delivery. Since their excellent properties, different aptamer-mediated drug delivery systems had been developed for cancer ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218254/
Aptamers as delivery agents. Aptamers can be designed as targeting ligands, particularly when generated by cell-based SELEX, and can differentiate diseased cells from healthy cells, thus enabling the selective delivery of therapeutic compounds to target cells (Table 1).Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.sciencedirect.com/science/article/pii/S0167779911001132
Aptamer-mediated cell type-specific small interfering RNA (siRNA) delivery Also known as chemical antibodies, aptamers are poised to surpass natural antibodies in …Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.nature.com/articles/srep07851
Jan 19, 2015 · AS1411, binding to the receptor nucleolin on the cancer cell surface with high affinity and selectivity, was used to modify the UCNPs@MOF NCs with the capability of targeted biological imaging. By grafting AS1411 aptamers upon UCNPs@MOF NCs, target-specific drug delivery was achieved.Author: Kerong Deng, Zhiyao Hou, Xuejiao Li, Chunxia Li, Yuanxin Zhang, Xiaoran Deng, Ziyong Cheng, Jun Lin
https://www.sciencedirect.com/science/article/pii/S2211383516301186
Progress and perspectives on targeting nanoparticles for brain drug delivery. Author links open overlay panel Huile Gao. ... Cationic proteins and peptides, such as cationized bovine serum albumin (CBSA), could be used for adsorptive-mediated brain targeted drug delivery. ... Aptamer-mediated targeted delivery.Author: Huile Gao
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