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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
This proof-of-principle study demonstrated that an anti-TN-C aptamer could be used to target tumors (glioma, breast, and colon) that express high level of TN-C and that aptamers, in general, may have pharmacologic properties that make them excellent agents for tumor-specific drug delivery.Author: Partha Ray, Rebekah R. White
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218254/
The cell membrane is basically a dynamic lipid bilayer; therefore, this liposome nanostructure can efficiently increase cell permeability and enhance drug delivery. A cell-permeable sgc8-PEG-liposome nanostructure has also been reported for drug delivery . With approximately 250 aptamers on each liposome, this design leads to multiple aptamer ...Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.sciencedirect.com/science/article/pii/S0169409X18302473
An originality in this report consisted in the synthesis of a complementary DNA strand to the AS1411 aptamer able to disrupt the 3D structure of the aptamer and thus acting as an antidote to reverse the action of aptamer-mediated targeted drug delivery .Author: Walhan Alshaer, Walhan Alshaer, Hervé Hillaireau, Elias Fattal
https://tan.chem.ufl.edu/wp-content/uploads/sites/39/pubs/important-articles/Molecular%20aptamers%20for%20drug%20delivery.pdf
Molecular aptamers for drug delivery Weihong 3 Tan1,2, Hui Wang2, Yan Chen1,2,3, Xiaobing Zhang1, Haizhen Zhu1, Chaoyong Yang , Ronghua Yang1 and Chen Liu2 1State Key Laboratory ofChemo/Biosensing andChemometrics, CollegeBiology, Chemistry Chemical
https://www.nature.com/articles/nrd.2016.199
Nov 03, 2016 · There are three aptamers designated for use in ophthalmology, including one drug approved by the US Food and Drug Administration (FDA) (pegaptanib (Macugen)), and two in …Author: Jiehua Zhou, John Rossi
http://cancerres.aacrjournals.org/content/78/3/798
Feb 01, 2018 · Extracellular nanovesicles (ENV) released by many cells contain lipids, proteins, and nucleic acids that contribute to intercellular communication. ENVs have emerged as biomarkers and therapeutic targets but they have also been explored as drug delivery vehicles. However, for the latter application, clinical translation has been limited by low yield and inadequate targeting effects. ENV ...Author: Yuan Wan, Lixue Wang, Lixue Wang, Chuandong Zhu, Qin Zheng, Guoxiang Wang, Jinlong Tong, Yuan Fang, ...
https://pubs.acs.org/doi/full/10.1021/ja4117395
Aptamer–drug conjugates (ApDCs) are promising targeted drug delivery systems for reducing toxicity while increasing the efficacy of chemotherapy. However, current ApDC technologies suffer from problems caused by the complicated preparation and low controllability of drug–aptamer conjugation. To solve such problems, we have designed and synthesized a therapeutic module for solid phase ...Author: RuoWen Wang, Guizhi Zhu, Lei Mei, Yan Xie, Haibin Ma, Mao Ye, Feng-Ling Qing, Weihong Tan
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