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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218254/
Aptamers as delivery agents Aptamers can be designed as targeting ligands, particularly when generated by cell-based SELEX, and can differentiate diseased cells from healthy cells, thus enabling the selective delivery of therapeutic compounds to target cells (Table 1). Table 1 Aptamers for drug deliveryAuthor: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
http://www.eurekaselect.com/166036/article
Keywords:Aptamer, Cancer target therapy, Drug delivery system, Nanomaterials, Drug carrier, Nano-medicine Abstract:Aptamers are single-stranded DNA or RNA with 20-100 nucleotides in length that can specifically bind to target molecules via formed three-dimensional structures. These innovative targeting molecules have attracted an increasing interest in the biomedical field.Author: Fen He, Nachuan Wen, Daipeng Xiao, Jianhua Yan, Hongjie Xiong, Shundong Cai, Zhenbao Liu, Yanfei Liu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
These creative examples of combinatorial approaches demonstrate that aptamer-conjugated polymers and nanoparticles may be powerful platforms for targeted drug delivery and …Author: Partha Ray, Rebekah R. White
https://www.researchgate.net/publication/328159638_Aptamer_Based_Targeted_Drug_Delivery_Systems_Current_Potential_and_Challenges
Aptamers can bind to the receptors on the cell membrane and mediate themselves or conjugated nanoparticles to enter into cells. Therefore, aptamers can be served as ideal targeting ligands for drug...
https://www.dovepress.com/aptamer-drug-conjugate-targeted-delivery-of-doxorubicin-in-a-her3-apta-peer-reviewed-article-IJN
Aptamer–drug conjugate: targeted delivery of doxorubicin in a HER3 aptamer-functionalized liposomal delivery system reduces cardiotoxicityAuthor: Xiao-qian Dou, Hua Wang, Jing Zhang, Fang Wang, Gui-li Xu, Cheng-cheng Xu, Huan-hua Xu, Shen-si Xian...
https://www.sciencedirect.com/science/article/pii/S0169409X18302473
The concept of “magic bullet” is still inspiring research for targeted drug delivery systems that save normal cells and reach diseased ones. The unmet needs of cancer treatment do fit this paradigm, making this application of the main focuses of targeted drug delivery.Author: Walhan Alshaer, Walhan Alshaer, Hervé Hillaireau, Elias Fattal
https://tan.chem.ufl.edu/wp-content/uploads/sites/39/pubs/important-articles/Molecular%20aptamers%20for%20drug%20delivery.pdf
aptamer research is still in its infancy but is progressing at a rapid pace. SELEX: aptamer selection process The technologies involved in the SELEX process can vary from traditionalcapillaryelectrophoresisorflowcytometry to, most recently, microfluidic systems [40]. SELEX has undergone several refinements and modifications. Most advances
https://pubs.acs.org/doi/pdf/10.1021/ja4117395
ABSTRACT: Aptamer−drug conjugates (ApDCs) are promising targeted drug delivery systems for reducing toxicity while increasing the efficacy of chemotherapy. However, current ApDC technologies suffer from problems caused by the complicated preparation and low controllability of drug−aptamer conjugation. To solve
https://www.slideshare.net/AnuragPandey60/aptamers-based-drug-delivery-93903621
Apr 15, 2018 · APTAMER IN DRUG DELIVERY SYSTEM The prostate-specific membrane antigen (PSMA) is an important prostate cancer marker. The dual aptamer probe-an A10 aptamer for PSMA(+) prostate cancer cells, & a DUP-1 aptamer for PSMA(-) prostate cancer cells-was invented, & a drug loaded dual aptamer complex was constructed by loading doxorubicin, an anti-cancer drug, onto the A10 aptamer …
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