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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
This proof-of-principle study demonstrated that an anti-TN-C aptamer could be used to target tumors (glioma, breast, and colon) that express high level of TN-C and that aptamers, in general, may have pharmacologic properties that make them excellent agents for tumor-specific drug delivery.Author: Partha Ray, Rebekah R. White
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218254/
The cell membrane is basically a dynamic lipid bilayer; therefore, this liposome nanostructure can efficiently increase cell permeability and enhance drug delivery. A cell-permeable sgc8-PEG-liposome nanostructure has also been reported for drug delivery . With approximately 250 aptamers on each liposome, this design leads to multiple aptamer ...Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.sciencedirect.com/science/article/pii/S0167779911001132
Because each type of nanomaterial has different optical, electrochemical and mechanical properties, medical diagnostic and drug delivery agents with diverse characteristics can be used for different applications, moving aptamer-based nanomedicine closer to reality.Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.sciencedirect.com/science/article/pii/S0169409X18302473
Similar approaches of aptamer-functionalized, PLGA-based nanoparticles have been described for drug delivery in several types of tumors using different aptamers such as anti-NCL aptamer (AS1411) (for targeted delivery of paclitaxel to Glioma) , anti-MUC1 aptamer (for targeted delivery of paclitaxel to breast cancer) , and finally EpCAM (for ...Author: Walhan Alshaer, Walhan Alshaer, Hervé Hillaireau, Elias Fattal
https://www.nature.com/articles/nrd.2016.199
Nov 03, 2016 · Zhou, J. et al. Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge. Mol. Ther. 21 , 192–200 (2013).Author: Jiehua Zhou, John Rossi
https://tan.chem.ufl.edu/wp-content/uploads/sites/39/pubs/important-articles/Molecular%20aptamers%20for%20drug%20delivery.pdf
1. Aptamers for drug delivery Target name Aptamer Selection technique Delivery application Refs Epidermal growth factor receptor (EGFR) RNA Purified extracellular domain of EGFR Nanoparticle delivery [63] Immunoglobin heavy mu chain (IGHM) DNA Cell-SELEX Micelle nanoparticles for drug delivery [14] Mucin-1
https://www.basepairbio.com/drug-delivery/
Custom Aptamer Selection with Base Pair. Whether you have a cell type of interest or have identified a specific cell surface target, the first step in aptamer-mediated drug delivery is discovery of selective aptamers. Base Pair has discovered aptamers to cells, cell surface markers, small molecule drugs and drug metabolites.
https://www.slideshare.net/AnuragPandey60/aptamers-based-drug-delivery-93903621
Apr 15, 2018 · Aptamers for Targeted Drug Delivery, Partha Ray and Rebekah R. White & Department of Surgery, Duke University Medical Center, DUMC Box 103035, Durham, NC 27710, USA 2. Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems, Feng Jiang, International Journal of Molecular Sciences ISSN 1422-0067 3.
https://pubs.acs.org/doi/10.1021/nn901374b
Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles. Advanced Materials 2012, 24 (21) , 2890-2895. DOI: 10.1002/adma.201104797. Hongyu Zhou, Gaoxing Su, Peifu Jiao, Bing Yan.Author: Yen-An Shieh, Shu-Jyuan Yang, Ming-Feng Wei, Ming-Jium Shieh
https://www.basepairbio.com/drug-discovery-development/
Aptamer-drug conjugates can be used to deliver drugs to target cells and offer several advantages over antibody-drug conjugates. Directed delivery of drug compounds limits off-target effects. Increased delivery to target cells can lower the required dosage and improve efficacy. Aptamers can be selected to bind with a high degree of specificity ...
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