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https://www.oligotherapeutics.org/targeted-delivery-using-aptamers/
July 25, 2019 Currently, effective cell-targeted delivery tools for oligonucleotide therapeutics are limited. Aptamers that internalize into target cells have been shown to deliver a wide variety of nucleic acid therapeutics, from siRNAs
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218254/
They rival and, in some cases, surpass other molecular probes, such as antibodies. In this review, we highlight the recent progress in aptamer-mediated delivery for therapeutics and disease-targeting based on aptamer integration with a variety of nanomaterials, such as gold nanorods, DNA-micelles, DNA-hydrogels and carbon nanotubes.Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.sciencedirect.com/science/article/pii/S0169409X18302473
Similar approaches of aptamer-functionalized, PLGA-based nanoparticles have been described for drug delivery in several types of tumors using different aptamers such as anti-NCL aptamer (AS1411) (for targeted delivery of paclitaxel to Glioma) , anti-MUC1 aptamer (for targeted delivery of paclitaxel to breast cancer) , and finally EpCAM (for ...Author: Walhan Alshaer, Walhan Alshaer, Hervé Hillaireau, Elias Fattal
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806697/
Jan 05, 2010 · Moreover, this aptamer–micelle was found to have low CMC and low cytotoxicity to the cells . As such, this type of aptamer–micelle is proposed to be an efficient drug delivery vehicle for target cells without the need for internalization of the aptamer’s target molecule.Author: Yanrong Wu, Kwame Sefah, Haipeng Liu, Ruowen Wang, Weihong Tan
https://www.sciencedirect.com/science/article/pii/S0022202X17329640
Concordance of skin extracted aptamer with the IL-23 aptamer dylight 488 standard shows delivery of intact labeled macromolecules to these skin layers, providing evidence that the fluorescence images are not from dissociation of the label, though this cannot be …Author: Jon D. Lenn, Jessica Neil, Christine Donahue, Kellie Demock, Caitlin Vestal Tibbetts, Javier Cote-Si...
https://tan.chem.ufl.edu/wp-content/uploads/sites/39/pubs/important-articles/Molecular%20aptamers%20for%20drug%20delivery.pdf
Molecular aptamers for drug delivery Weihong 3 Tan1,2, Hui Wang2, Yan Chen1,2,3, Xiaobing Zhang1, Haizhen Zhu1, Chaoyong Yang , Ronghua Yang1 and Chen Liu2 1State Key Laboratory ofChemo/Biosensing andChemometrics, CollegeBiology, Chemistry Chemical
https://www.nature.com/articles/ncomms13580
Nov 24, 2016 · Delivery of siRNA to target cells is essential for in vivogene therapy. Here the authors demonstrate an oligonucleotide aptamer that targets therapeutic siRNA to a specific cell type.Author: Kewei Ren, Ying Liu, Jie Wu, Yue Zhang, Jing Zhu, Min Yang, Huangxian Ju
https://www.intechopen.com/online-first/aptamers-for-targeted-delivery-current-challenges-and-future-opportunities
Due to this, a number of aptamers are entering clinical trials. In summary, aptamer-mediated targeted delivery remains a work in progress; however, with bright results at in vivo level and several aptamer drugs in clinical trials, the coming decade will determine their efficiency at the clinical level.Author: Chetan Chandola, Muniasamy Neerathilingam
https://www.nature.com/articles/nrd.2016.199
Nov 03, 2016 · McNamara, J. O. et al. Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat. Biotechnol. 24, 1005–1015 (2006). One of …Author: Jiehua Zhou, John Rossi
http://cancerres.aacrjournals.org/content/78/3/798
Feb 01, 2018 · Figure 1. Schematics showing steps of experiments (not drawn to scale). The DCs were isolated from mouse bone marrow and multiplied in vitro.Cells were homogeneously labeled with aptamer-conjugated PEGylated cholesterol and then repeatedly filtrated through two filters with 10- and 5-μm pore size for generating ENVs.Author: Yuan Wan, Lixue Wang, Lixue Wang, Chuandong Zhu, Qin Zheng, Guoxiang Wang, Jinlong Tong, Yuan Fang, ...
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