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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043981/
Oct 30, 2010 · Recent advances in the development of escort aptamers to deliver and enhance the efficacy of other therapeutic agents have drawn enthusiasm in exploiting cell-type-specific aptamers as drug delivery vehicles. This review mainly focuses on the recent developments of aptamer-mediated targeted delivery systems.Author: Jiehua Zhou, John J. Rossi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
This proof-of-principle study demonstrated that an anti-TN-C aptamer could be used to target tumors (glioma, breast, and colon) that express high level of TN-C and that aptamers, in general, may have pharmacologic properties that make them excellent agents for tumor-specific drug delivery.Author: Partha Ray, Rebekah R. White
https://www.nature.com/articles/nrd.2016.199
Nov 03, 2016 · Nucleic acid aptamers offer several advantages over traditional antibodies, but their clinical translation has been delayed by several factors, including insufficient potency, lack of …Author: Jiehua Zhou, John Rossi
https://www.researchgate.net/publication/267365884_Aptamer-Nanoparticle_Bioconjugates_for_Drug_Delivery
The main focus will be on aptamer-incorporated nanoparticle systems for drug delivery purposes in order to assess the future potential of aptamers in the therapeutic area.
https://pubs.acs.org/doi/full/10.1021/ja4117395
Aptamer–drug conjugates (ApDCs) are promising targeted drug delivery systems for reducing toxicity while increasing the efficacy of chemotherapy. However, current ApDC technologies suffer from problems caused by the complicated preparation and low controllability of drug–aptamer conjugation. To solve such problems, we have designed and synthesized a therapeutic module for solid phase ...Author: RuoWen Wang, Guizhi Zhu, Lei Mei, Yan Xie, Haibin Ma, Mao Ye, Feng-Ling Qing, Weihong Tan
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024077
MUC1 protein is an attractive target for anticancer drug delivery owing to its overexpression in most adenocarcinomas. In this study, a reported MUC1 protein aptamer is exploited as the targeting agent of a nanoparticle-based drug delivery system. Paclitaxel (PTX) loaded poly (lactic-co-glycolic-acid) (PLGA) nanoparticles were formulated by an emulsion/evaporation method, and MUC1 aptamers ...
https://www.sciencedirect.com/science/article/pii/S0167779911001132
When combined with the large number of recently created DNA aptamers that specifically target a wide variety of cancer cells, this drug–aptamer conjugation method has broad implications for targeted drug delivery. Aptamer-mediated cell type-specific small interfering RNA (siRNA) deliveryAuthor: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.biologyonline.com/articles/targeted-drug-delivery-achieved
Nov 18, 2007 · These results mark the first ever example of targeted drug delivery using nanoparticle-aptamer bioconjugates. Significantly, the drug delivery was highly specific. Uptake of particles was not seen to be enhanced in cells which did not express the PSMA protein, indicating a …
https://www.sciencedirect.com/science/article/pii/S1549963414005255
Targeted delivery offers a significant advantage for the efficient delivery of therapeutic payload and/or imaging agents to a specific target site while minimizing the exposure to normal tissues.2, 20 One such potent surface molecule used for targeted drug delivery purpose is epithelial cell adhesion molecule (EpCAM), which is expressed at low ...Author: Manasi Das, Wei Duan, Sanjeeb K. Sahoo
https://phys.org/news/2005-11-drug-delivery-nanoparticle-aptamer-bioconjugates.html
Nov 01, 2005 · These results mark the first ever example of targeted drug delivery using nanoparticle-aptamer bioconjugates. Significantly, the drug delivery was highly specific.
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