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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051498/
As mentioned, the mammalian immune system has evolved to recognize repetitive motifs, therein questioning the potential of polymers to serve as effective materials for systemic drug delivery [55,56]. Clearly, the development of additional strategies for stabilizing delivery systems in blood is greatly needed [2,57–59].Author: Johan J. F. Verhoef, Thomas J. Anchordoquy
https://www.researchgate.net/publication/263104135_Questioning_the_Use_of_PEGylation_for_Drug_Delivery
Questioning the Use of PEGylation for Drug Delivery Article (PDF Available) in Drug Delivery and Translational Research 3(6) · December 2013 with 111 Reads How we measure 'reads'
https://europepmc.org/articles/PMC4051498
Furthermore, we feel that the accumulating evidence documenting the detrimental effects of PEG on drug delivery make it imperative that scientists in this field break their dependence on PEGylation, and develop improved approaches for achieving adequate circulation times in order to realize the enormous clinical benefits of targeted drug delivery.
https://rd.springer.com/article/10.1007/s13346-013-0176-5
Sep 25, 2013 · Polyethylene glycol (PEG) is widely utilized in drug delivery and nanotechnology due to its reported “stealth” properties and biocompatibility. It is generally thought that PEGylation allows particulate delivery systems and biomaterials to evade the immune system and thereby prolong circulation lifetimes. However, numerous studies over the past decade have demonstrated that PEGylation ...Author: Johan J. F. Verhoef, Thomas J. Anchordoquy
https://link.springer.com/10.1007/s13346-013-0176-5
Drug Delivery and Translational Research December 2013 , Volume 3, Issue 6 , pp 499–503 Cite as Questioning the use of PEGylation for drug deliveryAuthor: Johan J. F. Verhoef, Thomas J. Anchordoquy
http://www.ucdenver.edu/academics/colleges/pharmacy/Departments/PharmaceuticalSciences/DOPSFaculty/A-G/Pages/AnchordoquyTomPhD.aspx
Ultimately, the goal of these studies is to develop lipid-based delivery systems that elicit minimal immune responses upon repeat administration and preferentially target tumors. Another major focus in the lab is the use of exosomes and the exosomal pathway for drug delivery.
https://www.sciencedirect.com/science/article/pii/B9780081017500000027
Davis et al. described PEGylation in the 1970s , , to decrease the immunogenicity of non-human proteins, and now at least 15 registered PEGylated products are in clinical use with more in clinical trials .Several clinically used therapeutic proteins, such as diagnostics and ADCs, are chemically modified to add an additional function.Author: Sahar Awwad, Sahar Awwad, Claire Ginn, Steve Brocchini, Steve Brocchini
https://link.springer.com/journal/13346/3/6
Dec 06, 2013 · Drug Delivery and Translational Research. All Volumes & Issues. Volume 3, Issue 6, December 2013. ISSN: 2190-393X (Print) 2190-3948 (Online) In this issue (10 articles) Invited Review Article. Questioning the use of PEGylation for drug delivery. Johan J. F. …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839405/
Apr 12, 2016 · The MicroCor transdermal delivery system is a microstructure-based platform that incorporates the drug of interest into an array of solid-state, biodegradable microstructures. When these microstructures penetrate the outer layers of the skin, they dissolve rapidly to release the drug for local or systemic uptake.Author: Peng-Yu Yang, Huafei Zou, Elizabeth Chao, Lance Sherwood, Vanessa Nunez, Michael Keeney, Esi Ghartey...
https://www.researchgate.net/publication/338856845_The_Use_of_Lactose_as_an_Alternative_Coating_for_Nanoparticles
Nanoparticle-mediated drug delivery has long utilized PEGylation as a mechanism for reducing uptake by the reticuloendothelial system and extending circulation lifetimes. ... Questioning the Use ...
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