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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
The sgc8c aptamer is therefore a promising candidate for targeted drug delivery. Huang et al. covalently conjugated the anthracycline chemotherapeutic agent doxorubicin (Dox) to the sgc8c aptamer using an acid-labile hydrazone linkage. The idea was that, upon binding the receptor PTK7, the conjugate would be internalized and transported to the ...Author: Partha Ray, Rebekah R. White
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043981/
Oct 30, 2010 · Recent advances in the development of escort aptamers to deliver and enhance the efficacy of other therapeutic agents have drawn enthusiasm in exploiting cell-type-specific aptamers as drug delivery vehicles. This review mainly focuses on the recent developments of aptamer-mediated targeted delivery systems.Author: Jiehua Zhou, John J. Rossi
https://www.nature.com/articles/nrd.2016.199
Nov 03, 2016 · In addition, many aptamers are internalized upon binding to cellular receptors, making them useful targeted delivery agents for small interfering RNAs (siRNAs), microRNAs and …Author: Jiehua Zhou, John Rossi
https://www.sciencedirect.com/science/article/pii/S2162253118301306
The concept of intrinsic incorporation of gemcitabine into oligonucleotide was first reported by Ray et al. 51 In their study, gemcitabine was incorporated into oligonucleotides by mutant RNA polymerases, and gemcitabine-containing oligonucleotides were annealed to the aptamer for targeted drug delivery.Author: Jun Young Park, Ye Lim Cho, Ju Ri Chae, Sung Hwan Moon, Won Gil Cho, Yun Jung Choi, Soo Jin Lee, Won...
https://pubs.acs.org/doi/10.1021/nn901374b
Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles. Advanced Materials 2012, 24 (21) , 2890-2895. DOI: 10.1002/adma.201104797. Hongyu Zhou, Gaoxing Su, Peifu Jiao, Bing Yan.Author: Yen-An Shieh, Shu-Jyuan Yang, Ming-Feng Wei, Ming-Jium Shieh
http://cancerres.aacrjournals.org/content/78/3/798
Feb 01, 2018 · At 24-hour time point, paclitaxel-loaded AS1411-ENVs and ENVs released approximately 71.47% and 86.29% paclitaxel, respectively. The slow release of paclitaxel from nanovesicles is favorable for drug administration. Especially in targeted drug delivery, more drugs in vectors thus can be effectively delivered to the lesion.Author: Yuan Wan, Lixue Wang, Lixue Wang, Chuandong Zhu, Qin Zheng, Guoxiang Wang, Jinlong Tong, Yuan Fang, ...
https://www.sciencedirect.com/science/article/pii/S014296121630028X
Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance. Author links open overlay panel Juan Liu a 1 Tuo Wei a 1 Jing Zhao a Yuanyu Huang b Hua Deng a Anil Kumar a Chenxuan Wang a Zicai Liang b Xiaowei Ma a Xing-Jie Liang a. Show more.Author: Juan Liu, Tuo Wei, Jing Zhao, Yuanyu Huang, Hua Deng, Anil Kumar, Chenxuan Wang, Zicai Liang, Xiaowe...
https://pubs.acs.org/doi/10.1021/acsami.5b05522
Cu1.8S nanoparticles, possessing high photothermal conversion efficiency under a 980 nm laser, were chosen as photothermal agents. The mesoporous silica structure could be used for drug storage/delivery and modified with aptamer-modified GC-rich DNA-helix …Author: Yuanxin Zhang, Zhiyao Hou, Yakun Ge, Kerong Deng, Bei Liu, Xuejiao Li, Quanshun Li, Ziyong Cheng, Pi...
https://www.oligotherapeutics.org/targeted-delivery-using-aptamers/
July 25, 2019 Currently, effective cell-targeted delivery tools for oligonucleotide therapeutics are limited. Aptamers that internalize into target cells have been shown to deliver a wide variety of nucleic acid therapeutics, from siRNAs
https://www.researchgate.net/publication/45267619_Aptamers_for_Targeted_Drug_Delivery
The sgc8c aptamer is therefore a promising candidate for targeted drug delivery. Huang et al. [38] covalently conjugated the anthracycline chemothe rapeutic agent doxorubicin (Dox) to the sgc8c
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