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https://www.oligotherapeutics.org/targeted-delivery-using-aptamers/
July 25, 2019 Currently, effective cell-targeted delivery tools for oligonucleotide therapeutics are limited. Aptamers that internalize into target cells have been shown to deliver a wide variety of nucleic acid therapeutics, from siRNAs
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218254/
They rival and, in some cases, surpass other molecular probes, such as antibodies. In this review, we highlight the recent progress in aptamer-mediated delivery for therapeutics and disease-targeting based on aptamer integration with a variety of nanomaterials, such as gold nanorods, DNA-micelles, DNA-hydrogels and carbon nanotubes.Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
The perfect target for aptamer-mediated delivery is one that is highly expressed on all target cells, is efficiently internalized, and is not expressed on the surface of non-target cells. Although a perfect target may not exist, several aptamers against excellent targets have been identified.Author: Partha Ray, Rebekah R. White
https://www.sciencedirect.com/science/article/pii/S0169409X18302473
Similar approaches of aptamer-functionalized, PLGA-based nanoparticles have been described for drug delivery in several types of tumors using different aptamers such as anti-NCL aptamer (AS1411) (for targeted delivery of paclitaxel to Glioma) , anti-MUC1 aptamer (for targeted delivery of paclitaxel to breast cancer) , and finally EpCAM (for ...Author: Walhan Alshaer, Walhan Alshaer, Hervé Hillaireau, Elias Fattal
https://tan.chem.ufl.edu/wp-content/uploads/sites/39/pubs/important-articles/Molecular%20aptamers%20for%20drug%20delivery.pdf
Molecular aptamers for drug delivery Weihong 3 Tan1,2, Hui Wang2, Yan Chen1,2,3, Xiaobing Zhang1, Haizhen Zhu1, Chaoyong Yang , Ronghua Yang1 and Chen Liu2 1State Key Laboratory ofChemo/Biosensing andChemometrics, CollegeBiology, Chemistry Chemical
https://www.sciencedirect.com/science/article/pii/S0022202X17329640
Concordance of skin extracted aptamer with the IL-23 aptamer dylight 488 standard shows delivery of intact labeled macromolecules to these skin layers, providing evidence that the fluorescence images are not from dissociation of the label, though this cannot be …Author: Jon D. Lenn, Jessica Neil, Christine Donahue, Kellie Demock, Caitlin Vestal Tibbetts, Javier Cote-Si...
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