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The Delivery of Antisense RNA ThERapeutics (DARTER) Action Members is a highly dedicated group of scientists, whose goal is (through COST networking tools) to allow RNA-targeting nucleic acid drugs to reach their full potential and become a mainstream therapeutic option. Antisense oligonucleotides (ASOs) are a new class of drugs that, through very specific targeting, could correct genetic ...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · Delivery materials. Broadly speaking, RNA delivery can be mediated by viral and non-viral vectors. For viral RNA delivery, there has been a great deal of interest in engineering adeno-associated viruses to carry nucleic acid cargo []—however, this section will focus mainly on the development of non-viral materials (Table 1).Of the non-viral RNA delivery vehicles, nanoparticles …Author: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
https://antisenserna.eu/index.php/action-info/48-about/about-sc/2-antisense-rna
The Delivery of Antisense RNA ThERapeutics (DARTER) Action Members is a highly dedicated group of scientists, whose goal is (through COST networking tools) to allow RNA-targeting nucleic acid drugs to reach their full potential and become a mainstream therapeutic option. Antisense oligonucleotides (ASOs) are a new class of drugs that, through very specific targeting, could correct genetic ...
https://home.liebertpub.com/cfp/delivery-of-antisense-rna-therapeutics-turning-negative-resu/204/
Delivery of Antisense RNA Therapeutics: Turning Negative Results into a Positive Development- Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in the most promising areas of biotechnology and regenerative medicine, biomedical research, clinical medicine and surgery, technology and engineering, law ...
https://www.nature.com/articles/nrneurol.2017.148
Dec 01, 2017 · Antisense oligonucleotides (ASOs) were first discovered to influence RNA processing and modulate protein expression over two decades ago; however, …Author: C Rinaldi, Wood Mja.
https://pubs.acs.org/doi/10.1021/jacs.9b09043
Precisely assembled DNA nanostructures are promising candidates for the delivery of biomolecule-based therapeutics. Herein, we introduce a facile strategy for the construction of a branched DNA-based nanoplatform for codelivery of gene editing (sgRNA/Cas9, targeting DNA in the nucleus) and gene silencing (antisense, targeting mRNA in the cytoplasm) components for synergistic tumor therapy in ...Author: Jianbing Liu, Tiantian Wu, Tiantian Wu, Xuehe Lu, Xuehe Lu, Xiaohui Wu, Xiaohui Wu, Shaoli Liu, Shao...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475625/
Jun 16, 2008 · The potential use of antisense and siRNA oligonucleotides as therapeutic agents has elicited a great deal of interest. However, a major issue for oligonucleotide-based therapeutics involves effective intracellular delivery of the active molecules. In ...Author: Rudy Juliano, Md. Rowshon Alam, Vidula Dixit, Hyumin Kang
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201914751
Jan 29, 2020 · Systemic Brain Delivery of Antisense Oligonucleotides across the Blood–Brain Barrier with a Glucose‐Coated Polymeric Nanocarrier Dr. Hyun Su Min Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, …Author: Hyun Su Min, Hyun Jin Kim, Mitsuru Naito, Satomi Ogura, Kazuko Toh, Kotaro Hayashi, Beob Soo Kim, Sh...
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