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https://www.researchgate.net/publication/11247986_Hybrid_insulin_cocrystals_for_controlled_release_delivery
Hybrid insulin cocrystals for controlled release delivery Article in Nature Biotechnology 20(8):800-4 · September 2002 with 62 Reads How we measure 'reads'
https://www.nature.com/articles/nbt722
Jul 22, 2002 · Controlled release methods for the injectable delivery of therapeutic proteins use exogenous matrices to encapsulate the protein and thereby slow its absorption from the site of injection.Author: Mark L. Brader, Muppalla Sukumar, Allen H. Pekar, David S. McClellan, Ronald E. Chance, David B. Flo...
https://www.nature.com/articles/nbt722/email/correspondent/c1/
Jul 22, 2002 · Hybrid insulin cocrystals for controlled release delivery. ... Sukumar, M., Pekar, A. et al. Hybrid insulin cocrystals for controlled release delivery. Nat Biotechnol 20, 800–804 ...Author: Mark L. Brader, Muppalla Sukumar, Allen H. Pekar, David S. McClellan, Ronald E. Chance, David B. Flo...
https://www.researchgate.net/profile/Liang_Yin_Chu/publication/232057199_Controlled_release_systems_for_insulin_delivery/links/55e51d6a08ae2fac4722fcd7.pdf
recent (2000 – 2004) patents on the controlled release systems for insulin delivery, including those for injectable, oral, pulmonary and transdermal delivery, and the glucose-responsive ...
https://www.sciencedirect.com/science/article/pii/S0165614712002131
The role of co-crystals in pharmaceutical design. Author links open overlay panel Jonathan W. Steed. ... The lipophilic formulation was designed to provide a slow-release profile compatible with an improved physiological insulin profile. ... et al.Hybrid insulin cocrystals for controlled release delivery. Nat. Biotechnol., 20 (2002), pp. 800-804.Author: Jonathan W. Steed
https://www.sciencedirect.com/science/article/pii/S0144861717300851
May 15, 2017 · Sustained and controllable release of insulin is strongly required to achieve the ideal treatment of diabetes. We previously developed “self-assembly PEGylation retaining activity (SPRA) technology” via a host–guest interaction between PEGylated β-cyclodextrin and adamantane-appended insulin, and resulting PEGylated insulin was termed SPRA-insulin.Author: Tatsunori Hirotsu, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima
https://www.webmd.com/diabetes/features/insulin-delivery
Uneven insulin delivery. Because they send insulin into the body through the pores, jet injectors may not always deliver an accurate dose. Other options include an insulin patch.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
In vitro release of insulin, a model peptide, from liposomes in the bile salts solution was markedly reduced by coating the surface with the sugar chain portion of mucin or polyethylene glycol. Encapsulation of insulin with the sugar chain portion of mucin and that of polyethylene glycol completely suppressed the degradation of insulin in the ...
https://www.ijpsonline.com/articles/protein-and-peptide-drug-delivery-oral-approaches.html
Nov 10, 2006 · Brader ML, Sukumar M, Pekar AH, McClellan DS, Chance RE, Flora DB, et al. Hybrid insulin cocrystals for controlled release delivery. Nat Biotechnol 2OO2;2O:8OO-4. Bernkop SA. The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins. J Control Release l998;52:l-l6.Author: Jessy Shaji, V Patole
https://www.linkedin.com/in/bioactive
View mark brader’s profile on LinkedIn, the world's largest professional community. mark has 5 jobs listed on their profile. ... Hybrid insulin cocrystals for controlled release delivery. Nature ...Title: Biopharmaceutical Development …
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