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https://pubs.acs.org/doi/10.1021/bc900261c
This article reviews the hybrids (different materials used in one delivery system) of nonviral vectors for gene delivery including hybrids between cationic lipids and helper lipids, conjugates of peptides or targeting moieties and lipids, and hybrids of cationic liposomes and polymers.Author: Shubiao Zhang, Yinan Zhao, Budiao Zhao, Bing Wang
https://www.ncbi.nlm.nih.gov/pubmed/20205418
Jun 16, 2010 · Hybrids of nonviral vectors for gene delivery. Zhang S(1), Zhao Y, Zhao B, Wang B. Author information: (1)Dalian Nationalities University, Liaoning, China. [email protected] <[email protected]> Gene transfer has been a critical step for gene therapy. Viral vectors and nonviral vectors are commonly used for gene transfer.Author: Shubiao Zhang, Yinan Zhao, Budiao Zhao, Bing Wang
https://www.researchgate.net/publication/41806059_Hybrids_of_Nonviral_Vectors_for_Gene_Delivery
This article reviews the hybrids (different materials used in one delivery system) of nonviral vectors for gene delivery including hybrids between cationic lipids and helper lipids, conjugates of ...
https://pubs.rsc.org/en/content/articlelanding/2019/md/c9md00275h
Non-viral transfection vectors: are hybrid materials the way forward? ... efficient carriers are needed for successful gene delivery. Recombinant viruses are among the earliest described vectors. Unfortunately, they have severe drawbacks such as toxicity and immunogenicity. In this regard, the development of non-viral transfection vectors has ...Author: A. Gigante, M. Li, S. Junghänel, S. Junghänel, C. Hirschhäuser, S. Knauer, C. Schmuck
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Keywords: Chemical delivery, gene therapy, non viral delivery systems, physical delivery, viral delivery systems INTRODUCTION Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[ 1 ]
https://www.researchgate.net/publication/322394677_Non-Viral_Vectors_for_Gene_Delivery
Non-viral vectors are a preferred method of gene transfer due to potential safety and manufacturing benefits but suffer from lower delivery efficiencies compared to viral vectors.
https://www.nature.com/articles/nrg3763
Jul 15, 2014 · Non-viral vectors for gene-based therapy. Hao Yin Hao Yin is a postdoctoral associate at Massachusetts Institute of Technology, Cambridge, USA. He received his B.S. in biochemistry at Nanjing University, China, and his Ph.D. in toxicology from the School of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, USA.Author: Hao Yin, Rosemary L. Kanasty, Ahmed A. Eltoukhy, Arturo J. Vegas, Arturo J. Vegas, J. Robert Dorkin,...
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of low cost, more reproducible and do …Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.the-scientist.com/news/viral-vs-nonviral-in-gene-therapy-which-vector-will-prevail-56938
Jun 22, 1998 · The director of the University of Alabama at Birmingham's gene therapy program also noted that viral vectors have generated more research activity than nonviral vectors. However, nonviral backers think their delivery vehicles for therapeutic genetic material promise greater impact in …
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