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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475625/
Jun 16, 2008 · The potential use of antisense and siRNA oligonucleotides as therapeutic agents has elicited a great deal of interest. However, a major issue for oligonucleotide-based therapeutics involves effective intracellular delivery of the active molecules.Author: Rudy Juliano, Md. Rowshon Alam, Vidula Dixit, Hyumin Kang
https://academic.oup.com/nar/article/36/12/4158/1132931
Jun 16, 2008 · Abstract. The potential use of antisense and siRNA oligonucleotides as therapeutic agents has elicited a great deal of interest. However, a major issue for oligonucleotide-based therapeutics involves effective intracellular delivery of the active molecules.Author: Rudy Juliano, Md. Rowshon Alam, Vidula Dixit, Hyumin Kang
https://www.sciencedirect.com/science/article/pii/S1461534798000984
The development of antisense oligonucleotides as therapeutic agents has progressed significantly over the past 10–15 years. In order for antisense oligodeoxynucleotides to become effective therapeutic agents, improvement in the delivery and distribution of these compounds must occur.Author: Keith J Miller, Sudip K Das
https://www.researchgate.net/publication/247167339_Antisense_oligonucleotides_Strategies_for_delivery
The development of antisense oligonucleotides as therapeutic agents has progressed significantly over the past 10–15 years. In order for antisense oligodeoxynucleotides to become effective ...
https://www.nature.com/articles/nrneurol.2017.148
Dec 01, 2017 · Antisense oligonucleotides (ASOs) were first discovered to influence RNA processing and modulate protein expression over two decades ago; however, …Author: C Rinaldi, Wood Mja.
https://www.sciencedirect.com/science/article/pii/S1549963418300133
Therefore, many non-covalent delivery strategies have been developed, including lipid nanoparticles, bolaamphiphile-based nanocomplex, and DNA nanostructures. Examples of delivery strategies for antisense antibacterial therapy have been shown in Table 1.Author: Xiao-Yan Xue, Xing-Gang Mao, Ying Zhou, Zhou Chen, Yue Hu, Zheng Hou, Ming-Kai Li, Jing-Ru Meng, Xia...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248909/
Apr 16, 2018 · Unfortunately, PMOs, like all antisense oligonucleotides, exhibit limited delivery into the nucleus of cells. To improve PMO delivery, multiple strategies have been explored, such as the covalent attachment of cationic dendrimers or side-chains.Author: Justin M. Wolfe, Colin M. Fadzen, Rebecca L. Holden, Monica Yao, Gunnar J. Hanson, Bradley L. Pentel...
https://www.academia.edu/6890653/Antisense_Technology_Oligonucleotides_and_its_Delivery_Strategies
oligonucleotides have predominant role in its delivery for various diseases. Objective: Antisense compounds are biological molecules consisting of small ribonucleic acid (RNA) or deoxyribonucleic acid (DNA) segments (Oligonucleotide) which have
https://www.amazon.com/Delivery-Strategies-Antisense-Oligonucleotide-Therapeutics/dp/0849347785
With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating ...Author: Saghir Akhtar
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