Antisense Therapy Delivery

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Antisense oligonucleotides in therapy for ...

    https://www.sciencedirect.com/science/article/pii/S0169409X15000435
    In rats, intranasal delivery of antisense oligonucleotides was found to lead to good distribution throughout the brain, and was able to slow down intracerebral tumour growth . These studies hence indicate that intranasal delivery may become a viable option for antisense oligonucleotide delivery in the future. 3. Chemical modificationsAuthor: Melvin M. Evers, Lodewijk J.A. Toonen, Willeke M.C. van Roon-Mom

Antisense oligonucleotides: the next frontier for ...

    https://www.nature.com/articles/nrneurol.2017.148
    Dec 01, 2017 · Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and ... A. Nanoparticle delivery of antisense oligonucleotides and their application in the exon skipping strategy ...Author: C Rinaldi, Wood Mja.

Antisense Oligonucleotide - an overview ScienceDirect Topics

    https://www.sciencedirect.com/topics/neuroscience/antisense-oligonucleotide
    Antisense oligonucleotide therapy has gained popularity since the late 1980s. Advances in this field are directly related to improved technology, allowing synthesis of research quantities of oligonucleotides and the explosive growth of knowledge of viral, animal, and human genomic sequences.

Mechanisms and strategies for effective delivery of ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475625/
    Jun 16, 2008 · The potential use of antisense and siRNA oligonucleotides as therapeutic agents has elicited a great deal of interest. However, a major issue for oligonucleotide-based therapeutics involves effective intracellular delivery of the active molecules.Author: Rudy Juliano, Md. Rowshon Alam, Vidula Dixit, Hyumin Kang

Applications of Lipidic and Polymeric Nanoparticles for ...

    https://www.intechopen.com/books/antisense-therapy/applications-of-lipidic-and-polymeric-nanoparticles-for-sirna-delivery
    The antisense technology that emerged with the discovery of RNA interference nearly 20 years ago has gained a significant place in gene therapy. siRNA, one of two important components of RNA interference, efficiently downregulates gene expression in human cells, so it has the potential to eradicate disease. siRNA delivery systems, which can be applied both systemically and locally in different ...Author: Behiye Şenel, Gülay Büyükköroğlu

Antisense Therapy in Neurology - PubMed Central (PMC)

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251390/
    Aug 02, 2013 · Although promising, the headway of antisense therapy in the clinical realm has been quite slow. To better appreciate the current status of AO drug therapies, it is important to consider the hurdles that AOs have had to overcome. The first of these hurdles is drug delivery.Author: Joshua J. A. Lee, Toshifumi Yokota

Antisense Therapy: An Overview IntechOpen

    https://www.intechopen.com/books/antisense-therapy/antisense-therapy-an-overview
    The main obstacles that remained in cancer gene therapy and antisense therapy are the lack of delivery systems that successfully deliver an efficacious dose of a therapeutic gene (s) or antisense drug(s) to the targeted tumor site. Targeted gene or antisense drug delivery to distant tumors for therapeutic approaches is a demanding task that ...Author: Shashwat Sharad

Global Markets for Drug Delivery in Cancer, Forecast to ...

    https://www.prnewswire.com/news-releases/global-markets-for-drug-delivery-in-cancer-forecast-to-2028---includes-coverage-on-antisense-rnai-and-gene-therapy-for-cancer-301022330.html
    Global Markets for Drug Delivery in Cancer, Forecast to 2028 - Includes Coverage on Antisense, RNAi and Gene Therapy for Cancer

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