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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089357/
Brain tumors are inherently difficult to treat in large part due to the cellular blood-brain barriers (BBB) that limit the delivery of therapeutics to the tumor tissue from the systemic circulation. Virtually no large-molecules, including antibody-based ...Author: Ann-Marie Chacko, Chunsheng Li, Daniel A. Pryma, Steven Brem, George Coukos, Vladimir R. Muzykantov
https://www.nature.com/articles/s41541-020-0172-y
Mar 24, 2020 · Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice. ... Anti-tau antibody titer in brain lysates and …Author: Hiroki Takeuchi
https://www.antibodysociety.org/overcoming-antibody-delivery-challenges/
Sep 07, 2017 · In the opening talk of this session, Jasi Atwal (Genentech) will present on bispecific antibodies to increase antibody delivery across the BBB into the brain. One arm of the bispecific binds to a receptor enriched at the BBB, such as transferrin receptor or CD98 heavy chain. The other arm of the bispecific binds to the brain target of interest. M.
https://www.gene.com/stories/how-to-get-into-the-brain
Dec 01, 2015 · This finding challenges a widely held belief that the BBB is compromised in Alzheimer’s disease, and that therapeutic antibodies can work themselves into the brain to treat the disease. Ultimately, what we need are new ways to overcome this fundamental problem in antibody delivery to the brain. We may have found one.
https://www.nature.com/articles/s41598-019-45577-2
Jun 25, 2019 · SUS enhances antibody delivery to the brain. We have previously demonstrated that the RN2N anti-tau antibody in the scFv format, when combined with SUS, reaches a …Author: Phillip W. Janowicz, Gerhard Leinenga, Jürgen Götz, Rebecca M. Nisbet
https://wyss.harvard.edu/technology/brain-targeting-shuttles-for-drug-delivery-and-diagnostics/
Jun 13, 2019 · Antibody-based strategy for delivering drugs and diagnostics across the blood-brain barrier. In its Brain Targeting Program, a Wyss team led by Founding Director Donald Ingber, M.D., Ph.D. and Staff Program Lead James Gorman, M.D., Ph.D. is developing improved approaches to target drugs and diagnostics to the brain.Leveraging the human blood-brain barrier (BBB) Chip technology …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000699/
Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound. ... targeted drug delivery to the brain can be achieved using transcranial focused ultrasound (FUS), which transiently increases the permeability of the blood-brain barrier (BBB) for localized delivery of ...Author: Jessica F. Jordão, Jessica F. Jordão, Emmanuel Thévenot, Kelly Markham-Coultes, Tiffany Scarcelli, T...
https://www.sciencedirect.com/science/article/pii/S0304419X11000400
However, the delivery of engineered antibody fragments across BBB can be enhanced by numerous methods used for the delivery of intact antibodies . 5.7. Stem cell-mediated antibody delivery. A recently identified approach for the delivery of antibodies to cancer in the brain is the use of stem cells as antibody delivery vehicles.Author: Richard T. Frank, Karen S. Aboody, Joseph Najbauer
https://www.sciencedirect.com/science/article/pii/0169409X9500005R
advanced drug delivery reviews ELSEVIER Advanced Drug Delivery Reviews 15 (1995) 53-72 Antibody delivery through the blood-brain barrier Ulrich Bickel* Institute of Physiology, Philipps-University, Marburg, Deutschhausstr. 2, 35033 Marburg, Germany (Received 10 March 1995; accepted 30 March 1995) Abstract The diagnosis and therapy of diseases of the central nervous system could benefit from ...Author: Ulrich Bickel
https://denalitherapeutics.com/science/engineering
Engineering Brain Delivery The human brain contains approximately 400 miles of blood vessels. These blood vessels are lined by closely linked endothelial cells to form the Blood-Brain Barrier (BBB), which protects the brain from toxins by regulating the transfer of proteins, nutrients and waste products.
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