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https://www.sciencedirect.com/science/article/pii/0169409X9500005R
advanced drug delivery reviews ELSEVIER Advanced Drug Delivery Reviews 15 (1995) 53-72 Antibody delivery through the blood-brain barrier Ulrich Bickel* Institute of Physiology, Philipps-University, Marburg, Deutschhausstr. 2, 35033 Marburg, Germany (Received 10 March 1995; accepted 30 March 1995) Abstract The diagnosis and therapy of diseases of the central nervous system could benefit from ...Author: Ulrich Bickel
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089357/
4.2 Enhancing antibody delivery through blood-brain barrier disruption (BBBD) The transient disruption of the physical barrier presented by BBB and/or BBTB is another approach to improving CNS delivery of agents that would typically be impermeable.Author: Ann-Marie Chacko, Chunsheng Li, Daniel A. Pryma, Steven Brem, George Coukos, Vladimir R. Muzykantov
https://www.sciencedirect.com/science/article/abs/pii/0169409X9500005R
Because the size of even small antibody fragments (Fv, Fab) severely limits attempts to increase the delivery by passive diffusion through the intact BBB, methods that are under evaluation try either to circumvent the barrier by direct administration into cerebrospinal fluid or brain tissue, or to disrupt the barrier temporarily by hyperosmotic ...Author: Ulrich Bickel
https://theconversation.com/explainer-what-is-the-blood-brain-barrier-and-how-can-we-overcome-it-75454
Apr 05, 2017 · In a new study, we have shown that by temporarily opening the blood–brain barrier, ultrasound allows more of a therapeutic antibody into the brain, improving Alzheimer’s-like …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745584/
We briefly review the protective role of maternal antibodies during fetal development and at early postnatal stages. We describe antibody delivery to fetuses, particularly in the context of the developing blood–brain barrier (BBB), and present the essential concepts regarding the adult BBB, together with existing information on the prenatal developing BBB.Author: Czeslawa Kowal, Andrew Athanassiou, Huiyi Chen, Betty Diamond, Betty Diamond
https://www.worldpreclinicalcongress.com/Blood-Brain-Barrier/
11:15 Delivery of Transferrin Receptor-Targeted Nanoparticles and Biologics to the Brain Via Transport Through the Blood-Brain Barrier. Torben Moos, PhD, Professor, Section for Neurobiology, Aalborg University. Directed delivery to the brain using targeted therapeutics represents a feasible method for drug delivery to the CNS.
https://www.cell.com/neuron/fulltext/S0896-6273(15)01030-2
Jan 06, 2016 · Delivery of antibody therapeutics into the brain to treat central nervous system (CNS) diseases has been a major drug development challenge. With the support of astrocytes and pericytes, a monolayer of endothelial cells creates the blood-brain barrier (BBB), which serves to restrict movement of substances from the circulating blood to the CNS.Author: Y. Joy Yu Zuchero, Xiaocheng Chen, Nga Bien-Ly, Daniela Bumbaca, Raymond K. Tong, Xiaoying Gao, Shuo...
https://www.nature.com/articles/s41598-019-45577-2
Jun 25, 2019 · Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody Skip to main content Thank you for visiting nature.com.Author: Phillip W. Janowicz, Gerhard Leinenga, Jürgen Götz, Rebecca M. Nisbet
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