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https://link.springer.com/article/10.1007/s11095-007-9367-4
Jun 19, 2007 · The results indicate that the encapsulation of insulin into mucoadhesive nanoparticles was a key factor in the improvement of its oral absorption and oral bioactivity. To evaluate the pharmacological activity of insulin-loaded alginate/chitosan nanoparticles following oral dosage in diabetic rats.Author: B. Sarmento, A. Ribeiro, F. Veiga, P. Sampaio, R. Neufeld, D. Ferreira
https://www.researchgate.net/profile/Bruno_Sarmento/publication/6258833_AlginateChitosan_Nanoparticles_are_Effective_for_Oral_Insulin_Delivery/links/02e7e514c279a3cccb000000/Alginate-Chitosan-Nanoparticles-are-Effective-for-Oral-Insulin-Delivery.pdf?origin=publication_detail
Research Paper Alginate/Chitosan Nanoparticles are Effective for Oral Insulin Delivery B. Sarmento,1,5 A. Ribeiro,2 F. Veiga,2 P. Sampaio,3 R. Neufeld,4 and D. …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614711/
Jul 31, 2008 · The chitosan-alginate nanoparticles are carried out at ambient temperature, preparation is simple, rapid, and reliable. CS/ALG nanoparticles are obtained spontaneously under very mild conditions. The preparation of nifedipine loaded CS/ALG nanoparticles are relatively difficult.Author: Ping Li, Ya-Ni Dai, Jun-Ping Zhang, Ai-Qin Wang, Qin Wei
https://www.sciencedirect.com/science/article/pii/S007967001200041X
Oral delivery with alginate/chitosan nanoparticles led to a much improved and prolonged hypoglycemic effect as compared to native chitosan nanoparticles. The hypoglycemic effect that was sustained for less than 12 h in the case of native chitosan nanoparticles was prolonged up to 24 h using alginate/chitosan nanoscale formulations [46] .Author: Piyasi Mukhopadhyay, Roshnara Mishra, Dipak Rana, Patit P. Kundu
https://www.sciencedirect.com/science/article/pii/S0141813014005844
Chitosan-alginate (CS/ALG) nanoparticles were prepared by formation of an ionotropic pre-gelation of an alginate (ALG) core entrapping insulin, followed by chitosan (CS) polyelectrolyte complexation, for successful oral insulin administration.Author: Piyasi Mukhopadhyay, Souma Chakraborty, Sourav Bhattacharya, Roshnara Mishra, P.P. Kundu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534302/
Alginate (Alg) and chitosan (Chit) are naturally degradable materials that have been used in the oral delivery of peptides and proteins.15,16 Alg and Chit can crosslink together through electrostatic force to form nanoparticles that possess protective abilities as well as the ability to improve permeability and bioadhesion.15,17–20Author: Xiaoyang Li, Jianping Qi, Yunchang Xie, Xi Zhang, Shunwen Hu, Ying Xu, Yi Lu, Wei Wu
https://www.frontiersin.org/articles/10.3389/fphar.2020.00317/full
The poor solubility and permeability of most chemotherapeutic drugs lead to unsatisfactory bioavailability combined with insufficient drug concentration. In this study, positively charged nanoparticles based on chitosan were developed and synthesized to enhance tumor penetration capability of 10-Hydroxycamptothecin (HCPT) in order to improve the chemotherapeutic effect of melanoma. The …
https://www.mdpi.com/1420-3049/22/10/1707/pdf
Andreani et al. found evidence that silica nanoparticles coated with hydrophilic polymers (chitosan, sodium alginate and polyethylene glycol) can function as mucoadhesive carriers for oral insulin administration [21]. Further, Chronopoulou et al. developed an optimised drug delivery carrier (chlorhexidine) for oral mucosa use, able to deliver bioactive molecules in situ, using chitosan-based nanoparticles …Author: Vinicius B. V. Maciel, Cristiana M. P. Yoshida, Susana M. S. S. Pereira, Francisco M. Goycoolea, Tel...
https://www.degruyter.com/view/journals/jbcpp/31/2/article-20190147.xml?language=en
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