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https://jdh.adha.org/content/jdenthyg/82/suppl_2/10.full.pdf
local antimicrobials versus SRP alone. These findings strongly support the use of locally administered antimicrobials in combination with SRP in patients with chronic periodontitis, especially those at risk for disease progression. The first local delivery system approved for use by the US Food and Drug Administration (FDA) was calledAuthor: David W. Paquette, Maria Emanuel Ryan, Rebecca S. Wilder
https://www.sciencedirect.com/science/article/pii/S1877132719300314
Usually, there is no remaining bone defect, so no local antibiotic carrier is needed. The restored soft tissue cover will deliver adequate antimicrobial levels. In Type 3 defects, there is a need for high-level antibiotic release, together with bone ingrowth to restore bony integrity and prevent fracture.Author: Max Mifsud, Martin McNally
https://mysandiegodentalimplant.com/antibiotics/locally-delivered-antibiotics/
The advantages of using locally delivered antibiotics include the delivery of a high concentration of antibiotics to a localized area without systemic involvement, prolonged release over time, minimal risk of developing bacterial resistance, elimination of gastrointestinal or other adverse effects related to the use of systemic antibiotics as well as reduced risk of noncompliance with systemic antibiotic regimens.
http://www.kelleyperio.com/local-delivery-antimicrobials.html
Local Delivery Antimicrobials. Important- Please be aware that local delivery antimicrobials (LDAs) which are injected into deep pockets (like tetracyclines (Actisite®) including doxycycline (Atridox®) and minocycline (Arestin®), metronidazole (Elyzol®) and chlorhexidine (Periochip®)) are not a substitute for surgical treatment where needed.
http://www.knoxperio.com/procedures/periodontal-disease-treatments/locally-delivered-antibiotics/
Local delivery antimicrobials are medications that are delivered directly into periodontal pockets to suppress or eradicate periodontal bacteria. Local delivery antimicrobials may contain an antibiotic agent such as tetracycline, minocycline or metronidazole that’s released into the pocket over time.
https://www.ncbi.nlm.nih.gov/pubmed/29539751
Some techniques for applying antimicrobials subgingivally, such as subgingival irrigation, involve local delivery but not controlled-release. Controlled-release local delivery systems, in which the antimicrobial is available at therapeutic levels for several days, have been evaluated in several forms and using different antimicrobials.Author: Kenneth S. Kornman
https://www.sciencedirect.com/science/article/pii/S0939641100000862
Local delivery of antimicrobial agents using controlled release systems should be considered as adjunctive to mechanical debridement for the treatment of localized forms of periodontal destruction. This article reviews various types of delivery systems evaluated in practical periodontal therapy.Author: K Schwach-Abdellaoui, N Vivien-Castioni, R Gurny
https://www.researchgate.net/publication/12478485_Local_delivery_of_antimicrobial_agents_for_the_treatment_of_periodontal_disease
Local delivery of antimicrobial agents using controlled release systems should be considered as adjunctive to mechanical debridement for the treatment of localized forms of periodontal destruction.
https://www.sciencedirect.com/science/article/pii/S1532338212700131
Local antimicrobials. The use of local antimicrobials has been evaluated in the treatment of localized periodontitis lesions, either as an adjunct to SRP in the treatment of chronic periodontitis or in the treatment of relapsing periodontal lesions in patients undergoing maintenance therapy. In the past years, 2 main questions have been raised.Author: David Herrera, Paula Matesanz, Antonio Bascones-Martínez, Mariano Sanz
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