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https://www.nursingtimes.net/clinical-archive/neurology/rectal-drug-administration-in-adults-how-when-why-22-02-2016/
Rectal absorption results in more of the drug reaching the systemic circulation with less alteration on route. As well as being a more effective route for delivering medication, rectal administration also reduces side-effects of some drugs, such as gastric irritation, nausea and vomiting (Tortora and Derrickson, 2008).
https://clinicalgate.com/rectal-and-vaginal-drug-delivery/
The advantages and limitations of rectal drug administration are outlined in Box 42.2. Several categories of rectal preparations for drug delivery are available: suppositories, rectal capsules, rectal solutions, emulsions and suspensions, powders and tablets for rectal solutions and suspensions, semi-solid rectal preparations, rectal foams and rectal tampons.
https://www.tandfonline.com/doi/abs/10.1080/10837450.2018.1484766
Dec 28, 2017 · Drug delivery via the rectum is a useful alternative route of administration to the oral route for patients who cannot swallow. Traditional rectal dosage forms have been historically used for localized treatments including delivery of laxatives, treatment of hemorrhoids and for delivery …Author: Trusha J. Purohit, Sara M. Hanning, Zimei Wu
https://pediatrics.aappublications.org/content/100/1/143
The drug appears in blood within 1 minute, and peak blood levels of most medications are achieved generally within 10 to 15 minutes, which is substantially faster than when the same drugs are administered by the orogastric route. 76 The fentanyl Oralet™ was developed to take advantage of oral transmucosal absorption for the painless administration of an opioid in a formulation acceptable to …
https://www.slideshare.net/chiranjibi68/rectal-drug-delivery-systems
Jun 22, 2016 · CONCLUSION Rectal administration is truly explored as a potential drug delivery system particularly for drugs that are either too irritating for the gut or undergo extensive first pass metabolism. The rectal drug delivery system offer patients an option that is less invasive and the drug can be administered in unconscious and pediatric patients. Rectal drug delivery with the advantages of enhancement in drug …
http://globalresearchonline.net/journalcontents/v21-1/13.pdf
dosage form and drug absorption can be easily interrupted in cases of accidental overdose or suicide attempts. Drug which traditionally is only given parentally may be administered rectally. These advantages for rectal dosing require devices or formulations with specific features to give the desired drug delivery system.File Size: 359KB
https://www.slideshare.net/KamleshWadile/rectal-drug-delivery-system
Mar 15, 2016 · We conclude that, it is necessary not only to develop new drugs but also to optimize the different routes of administration, so as to increase effectiveness and minimize adverse effects. Rectal drug delivery with the advantages of enhancement in drug absorption and avoidance of first pass metabolism will undoubtedly be a pioneer in formulation of various challenging compounds. So, by improving some techniques towards good patient acceptability, rectal …
http://www.authorstream.com/Presentation/AJ07-983761-rectal-drug-delivery-system/
Apr 27, 2011 · REASEARCH ARTICLE (cont.) : o smotically-powered rectal drug delivery system An osmotically-powered rectal drug delivery system, was used for the rectal infusion of the model drug antipyrine. The system, which is slightly larger than a normal suppository, has a nominal pumping rate of 43 μl h − 1 over at least 30 h.
http://www.blissgvs.com/2016/12/26/advantages-and-disadvantages-of-suppositoriespessaries-or-rectalvaginal-route-of-drug-administration/
Dec 26, 2016 · Advantages and Disadvantages of Suppositories/Pessaries or rectal/vaginal route of drug administration…. ADVANTAGES OF SUPPOSITORIES. Over Oral Drug Administration: Avoid first pass metabolism. Introduce drugs into the body. Does not cause nausea and vomiting due to gastric irritation in case of oral therapy.
https://www.onlycology.com/2019/01/advantages-and-disadvantages-of-routes.html
Jan 21, 2019 · Advantages and disadvantages of routes of drug administration. You will get here Advantages and disadvantages of routes of drug administration. Different routes are Oral route, sublingual route, rectal route, parentral routes, subcutaneous, intravenous, Intramuscular. ORAL ROUTE. ● Convenient for repeated and prolonged use.
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