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https://www.ncbi.nlm.nih.gov/pubmed/15737247/
Comment in Respir Care. 2005 Aug;50(8):1083; author reply 1083-4. Inhalation is a very old method of drug delivery, and in the 20th century it became a mainstay of respiratory care, known as aerosol therapy. Use of inhaled epinephrine for relief of asthma was reported as early as 1929, in England ...Author: Joseph L Rau
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334339/
Feb 12, 2015 · The STACCATO ® is a novel breath-actuated inhalation delivery system, which uses heat to vaporize a thin film of the drug, which later condenses in the lungs into droplets or particles depending on the nature of the drug.78 In that case, the drug is dissolved in volatile solvent/solvent mixture which is sprayed over a metal substrate such as ...Author: Mariam Ibrahim, Rahul Verma, Lucila Garcia-Contreras
https://www.mannkindcorp.com/Collateral/Documents/English-US/Innovation%20In%20Drug%20Delivery%20by%20Inhalation.pdf
for rapidly absorbed drug products provided in patient-friendly formats, MannKind Corporation has developed an inhaled drug delivery technology based on dry-powder formulations delivered through discrete, breath-powered inhalers. Additionally, MannKind’s proprietary inert excipient, FDKP (fumaryl diketopiperazine), the primary component of
https://www.sciencedirect.com/topics/nursing-and-health-professions/drug-delivery-system
Drug Delivery System. A drug delivery system (DDS) is defined as a formulation or a device that enables the introduction of a therapeutic substance into the body and improves its efficacy and safety by controlling the rate, time, and place of release of drugs in the body.
https://www.pharmacytimes.com/news/differentiating-inhaled-delivery-systems-for-copd-drugs
Each one of the many available respiratory drug delivery systems has unique characteristics that dictate the ideal properties of the medications it may be paired with. There are no well-recognized guidelines to help clinicians select the best device, nor are there regulatory preferences for choosing one system …
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
1. Inhaled drug delivery puts drug where it is needed. 2. It requires low and fraction of oral dose i.e. drug content of one 4 mg tablet of salbutamol equals to 40 doses of meter doses. 3. Pulmonary drug delivery having very negligible side effects since rest of body is not exposed to drug. 4.
https://www.sciencedirect.com/science/article/pii/S0169409X14002300
Liposomal, polymeric and nanoparticle formulations of inhaled antibiotics are advanced drug delivery systems designed for the purposes of targeting drug delivery, sustaining drug release and enhancing the anti-microbial activities of antibiotics in the lungs.Author: Qi (Tony) Zhou, Sharon Shui Yee Leung, Patricia Tang, Thaigarajan Parumasivam, Zhi Hui Loh, Hak-Kim ...
https://www.pharmacytimes.com/resource-centers/copd/differentiating-inhaled-delivery-systems-for-copd-drugs
Nebulizers, which account for a majority of the remaining 10% of inhaled medication delivery, best meet these patients’ needs. Generic drug companies typically favor pMDIs because of their low materials costs, universal availability, and likelihood of demonstrating similarity to the innovator product.
https://www.hindawi.com/journals/crj/2018/2732017/
2.1. Step 1: Drug Particle/Droplet Deposition. As summarized in Figure 1, the first process following inhalation is the deposition of drug particles or droplets.A fraction of the dose gets deposited in the device, whereas the remaining fraction of particles or droplets gets delivered to the respiratory system.Author: Jens Markus Borghardt, Charlotte Kloft, Ashish Sharma
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are …
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