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https://www.ncbi.nlm.nih.gov/pubmed/29888992
Drug delivery via the rectum is a useful alternative route of administration to the oral route for patients who cannot swallow. Traditional rectal dosage forms have been historically used for localized treatments including delivery of laxatives, treatment of hemorrhoids and for delivery of antipyretics.Author: Trusha J. Purohit, Sara M. Hanning, Zimei Wu
https://www.tandfonline.com/doi/abs/10.1080/10837450.2018.1484766
Dec 28, 2017 · Drug delivery via the rectum is a useful alternative route of administration to the oral route for patients who cannot swallow. Traditional rectal dosage forms have been historically used for localized treatments including delivery of laxatives, treatment of hemorrhoids and for delivery …Author: Trusha J. Purohit, Sara M. Hanning, Zimei Wu
http://www.authorstream.com/Presentation/AJ07-983761-rectal-drug-delivery-system/
Apr 27, 2011 · Advantages: The drug causing severe nausea & vomiting, the oral administration may cause emesis, so in such cases this route can be used. Irritation to stomach & small intestine associated with certain drug can be avoided.
https://www.pharmatutor.org/articles/discussion-novel-rectal-drug-delivery-systems-recent-review
Rectal drug delivery systems used to deliver the drug by using mucoadhesive polymers is through the mucous membrane of the rectum. Rectal drug delivery is so essential when the oral medication is not possible, Intra venous(I.V) access is not possible and the patients have difficulty in swallowing, nausea and vomiting and for infants or children.
https://clinicalgate.com/rectal-and-vaginal-drug-delivery/
• Rectal and vaginal routes are used for local as well as systemic drug delivery and offer some unique advantages. • Both routes have a use in systemic drug delivery when the oral route is not available. • These routes are relatively less popular because of their anogenital nature and privacy aspects.
https://www.slideshare.net/KamleshWadile/rectal-drug-delivery-system
Mar 15, 2016 · • Definition: “Rectal drug delivery system means administration of drug or pharmaceutical preparations via rectum for local or systemic effect.” example: suppositories, rectum capsules, enemas, etc. • Rectal products may be: 1. Solid unit dosage form: Suppository. 2. Liquid unit dosage form: Enema.
https://www.nursingtimes.net/clinical-archive/neurology/rectal-drug-administration-in-adults-how-when-why-22-02-2016/
Rectal absorption results in more of the drug reaching the systemic circulation with less alteration on route. As well as being a more effective route for delivering medication, rectal administration also reduces side-effects of some drugs, such as gastric irritation, nausea and vomiting (Tortora and Derrickson, 2008).
https://www.slideshare.net/chiranjibi68/rectal-drug-delivery-systems
Jun 22, 2016 · Advantages of Rectal drug delivery system 1. Irritation to the stomach and small intestine associated with certain drugs can be avoided. E.g.- NSAIDs: Aspirin, Ibuprofen, Naproxen. 2. Absorption enhancement of many low molecular weight drugs, proteins and peptides. 3.
http://www.blissgvs.com/2016/12/26/advantages-and-disadvantages-of-suppositoriespessaries-or-rectalvaginal-route-of-drug-administration/
Dec 26, 2016 · Advantages and Disadvantages of Suppositories/Pessaries or rectal/vaginal route of drug administration…. ADVANTAGES OF SUPPOSITORIES. Over Oral Drug Administration: Avoid first pass metabolism. Introduce drugs into the body. Does not cause nausea and vomiting due to gastric irritation in case of oral therapy.
https://en.wikipedia.org/wiki/Rectal_administration
Another advantage of administering a drug rectally, is that it tends to produce less nausea compared to the oral route and prevents any amount of the drug from being lost due to emesis (vomiting).
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