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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900005/
Jan 01, 2014 · Worldwide, adenovirus vectors are the most common vector used in clinical trials: to date, there have been 476 human gene therapy studies that have been initiated using adenovirus vectors, representing 23.5% of all gene therapy trials (Journal of Gene Medicine, 2013).Author: Ronald G. Crystal
https://www.sciencedirect.com/science/article/pii/S2352304217300272
Among all currently available viral vectors, adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types. The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.Author: Cody S. Lee, Elliot S. Bishop, Ruyi Zhang, Ruyi Zhang, Xinyi Yu, Xinyi Yu, Evan M. Farina, Shujuan Y...
https://www.liebertpub.com/doi/10.1089/hum.2019.127
Dec 16, 2019 · We previously examined the ability of several serotypes of AAV to transduce cells in various tissues in mice after IV injection with particular focus on kidney gene delivery. 11 This study expands on this work to compare gene delivery by three different vector systems. This study also tested the utility of direct kidney injection of these vectors to avoid the natural ability of the glomerulus …Author: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry
https://www.takarabio.com/learning-centers/gene-function/viral-transduction/recombinant-virus-comparison
Viral gene delivery systems. Viral gene delivery allows the introduction and expression of a gene of interest in almost any mammalian cell type. However, selecting the best viral gene delivery system for your experimental aim can be challenging. Use the tables below to compare the characteristics of lentivirus, retrovirus, adenovirus,...
https://www.pnas.org/content/104/8/2596
Feb 20, 2007 · Thus, the unique mode of gene delivery by adenovirus vectors complements previously established genetic manipulation methods that achieve stable germ-line integration and will provide new opportunities for studies on male germ cell biology.Author: Masanori Takehashi, Mito Kanatsu-Shinohara, Kimiko Inoue, Narumi Ogonuki, Hiromi Miki, Shinya Toyoku...
https://www.vigenebio.com/adenovirus-packaging/
Adenovirus is a popular choice for gene delivery applications primarily because of its large packaging capacity, high transgene expression, and ability to infect most cell types. Note: Vigene offers only recombinant adenovirus products and services.
https://www.sciencedirect.com/topics/neuroscience/adenovirus-vector
Adenoviral vectors have been one of the most widely used viruses in gene delivery. They are nonenveloped, double-stranded (ds) DNA viral vectors with a packaging capacity of approximately 35 kb. Over 50 different adenoviral serotypes exist, grouped into six species. Recombinant adenoviral vectors are commonly derived from types 2 and 5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · The system has been utilized in the delivery of CFTR gene by lipid and adenoviral vectors to a specific site in the respiratory tract and is also used in the treatment of different cancers. However, low efficiency of transduction is the main problem of this system, because in cancer therapy one malignant cell can re-establish the tumor again.[ 20 – 22 ]
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